Disclosed herein is a hydrogel wound dressing produced by the steps of a) providing an hydrophobic polyol which has six hydroxyl groups, b) providing an hydrophilic diisocyanate obtained by reacting a second diisocyanate with a hydrophilic polyether diol, c) reacting the hydrophobic polyol with the hydrophilic diisocyanate to obtain a first prepolymer which includes 3 to 6 isocyanate groups, d) partially crosslinking the first prepolymer using a crosslinking agent to obtain a second prepolymer, and e) subjecting the second prepolymer to an end-capping reaction with a silane-containing compound to obtain the hydrogel wound dressing.

The present disclosure provides an anti-infective and anti-adhesive wound dressing based on nonspecific adhesion to bacteria, which includes a micron-sized porous membrane with polyolefin contained in its surface and does not contain any bactericide. According to the disclosure, through targeted selection of a material and surface structure of the porous membrane, nonspecific adhesion to the bacteria on the wound surface can be formed by good adaptability of its own surface energy and the structure of the porous membrane to surface energy of the bacteria, preventing the bacteria from penetrating into wound tissues and thus realizing the anti-infection for the bacteria and the anti-adhesion to the wound. Furthermore, no bactericide is required to be added, which not only reduces infection of the wound, but also weakens factors which are not conducive to wound healing, such as aggravation of inflammation caused by bacterial toxin released after bacterial rupture in traditional sterilization mechanisms.

A liquid dressing includes a solvent and a film-forming polymer that is dissolved in the solvent and that is made by a process including: providing an alkoxy group-containing silicone resin which is obtained by subjecting an orthosilicate compound and an acidic aqueous solution to a hydrolysis and polymerization reaction; providing an isocyanate group-containing prepolymer which is obtained by reacting a diisocyanate compound with a hydrophilic polyether diol; and subjecting the alkoxy group-containing silicone resin and the isocyanate group-containing prepolymer to a polymerization reaction so as to obtain the film-forming polymer.

The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.

The present invention provides a modified collagen comprising S-nitroso groups and a method of manufacture of such a modified collagen. Also provided is a wound dressing comprising such a modified collagen, particularly a wound dressing comprising a formulated composition comprising such a modified collagen.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The present disclosure provides a wound dressing composition comprising cross-linked hydrogel scaffold and embedded therein anti-bacterially active honey, said activity being determined by the detection of hydrogen peroxide production rate by said wound dressing; said wound dressing further comprising at least one of a photo-initiator and/or at least one UV cross linker, the total amount of said photo-initiator and/or UV cross linker is equal or less than 0.2% w/w out of the total weight of the wound dressing. Also disclosed herein is a method of preparing the wound dressing and methods of using the same with respect to wounds, the method of preparation comprises mixing a hydrogel forming mixture comprising hydrogel forming monomer or monomers, honey and at least one photo-initiator and/or at least one UV cross-liker to form a homogenous mixture; and subjecting the homogenous mixture to UV irradiation until said homogenous mixture solidifies.

The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

The invention relates to plasmids capable of expressing a protein targeting immune cells when transformed into a lactic acid bacterial cell, wherein the protein is chosen from the group consisting of murine and human CXCL12 1α; CXCL17 and Ym1. The invention further relates to lactic acid bacteria transformed with a said plasmid, as well as the use of said lactic acid bacteria for wound healing in humans and animals.