The present invention relates to a field of drug injection, and discloses a drug information detection device and a drug information detection type injection device. The drug information detection device is configured to detect an injected dose of an injection pen containing drug. The drug information detection device includes a housing, a rotary encoder configured to convert rotational information of the adjusting knob into drug injected dose information, and a control assembly. The rotary encoder includes an encoder body and a rotary block rotatably connected to the encoder body. The encoder body and the control assembly are electrically connected to each other. The housing is configured to cover the encoder body and the control assembly.

A trocar sleeve that isolates the surgical device or movement thereof to inhibit or prevent an established non-jet streaming condition from becoming a jet streaming condition and a method of inhibiting or preventing a jet streaming condition from occurring due to instrument obstruction.

Systems and methods of efficaciously washing body cavities, specifically including the nasal cavity, wherein a fluid flow is governed in at least one of degree and direction of issuance. Governing of the degree of fluid flow can involve an applicator that is affixable to a fluid source, wherein the applicator can variably constrain the degree of fluid flow being issued. Governing of the direction of issuance can involve the applicator, when affixed to the fluid source, issuing the fluid flow in a specific direction, relative to the fluid source, and an indicator of the fluid source's general orientation relative to vertical.

The present disclosure generally relates to fluid control valves for delivering and/or aspirating fluid during ophthalmic surgeries and procedures. In one embodiment, a valve assembly includes a first portion configured to fluidly couple with a gas supply line and a second portion configured to fluidly couple with a liquid supply line and an infusion line via two or more through channels. The first portion and the second portion are partitioned or separated from each other by a filter having a hydrophobic membrane configured to prevent the flow of liquids therethrough while allowing the free flow of gas. Accordingly, an infusion liquid may flow through the second portion while gases may be simultaneously aspirated through the first portion, without any liquids travelling into the gas supply line. The gas supply line may thus be utilized to vent or purge gases from the infusion line before or during performance of surgical procedures.

A delivery adapter which may be used as an interface between a syringe and a catheter hub is described.

A delivery adapter which may be used as an interface between a syringe and a catheter hub is described.

A localizable systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

In some aspects, the present disclosure relates to reactive multi-arm polymers that comprise (a) a core region, (b) multiple polymer arms, each polymer arm comprising at least one polymer segment and having a first end and a second end, the first end linked to the core region and (c) at least one first reactive moiety linked to the second end of each of the polymer arms, wherein the core region comprises a residue of a saccharide-based compound in which hydroxyl groups of a monosaccharide, disaccharide or oligosaccharide are replaced by C.sub.3-C.sub.10-hydroxyalkyloxy groups. In other aspects the present disclosure provides crosslinked hydrogels formed by covalently crosslinking such reactive multi-arm polymers with multifunctional crosslinking compounds that comprise a plurality of second reactive moieties that are reactive with the first reactive moieties of the reactive multi-arm polymer, as well as systems for forming such crosslinked hydrogels.

The present disclosure describes formulations, methods, and devices for intranasal delivery to a subject. The formulations may form two fluids which are immiscible at intranasal environmental conditions, such that when a formulation is delivered to a nasal cavity the two fluids separate with the more dense of the fluids settling below the less dense of the two fluids. One or more of the two fluids may concentrate a therapeutic agent or sampling fluid against a selected portion of the nasal cavity and the more dense of the two fluids can increase retention time of the formulation within the nasal cavity. Devices of the present disclosure may provide a convenient and effective way to deliver dual-density formulations intranasally.

A localizable systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.