Technologies are generally described for treatment of ear canal through a micro-dispenser-based treatment system. In some examples, ear canal irrigating fluids may be dispensed in a controlled volume and pressure through one or more micro-dispensers to dissolve and remove ear wax in a gentle and safe manner without harming the eardrum. Through positioning of the micro-dispensers or nozzles of the micro-dispensers, the fluid may be aimed directly at specific areas within the ear canal with a high degree of precision. The micro-dispenser(s) and an optional imaging device such as a camera may be integrated with an otoscope or a cannula for manual manipulation as well as for aiming the fluid jet with visual assessment of cleaning effectiveness

A localizable systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

An article is described including an article surface and a coating set comprising an optional tie coating or layer, a barrier coating or layer, and a pH protective layer. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. Examples of such an article are a thermoplastic syringe, vial, or blood collection tube with a coated interior portion containing a pharmaceutical preparation or other fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic syringe, vial, or blood collection tube. The tie coating or layer, if present, and the pH protective coating or layer protect the barrier layer from the contents of the syringe, vial, or blood collection tube.

An article is described including an article surface and a coating set comprising an optional tie coating or layer, a barrier coating or layer, and a pH protective layer. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. Examples of such an article are a thermoplastic syringe, vial, or blood collection tube with a coated interior portion containing a pharmaceutical preparation or other fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic syringe, vial, or blood collection tube. The tie coating or layer, if present, and the pH protective coating or layer protect the barrier layer from the contents of the syringe, vial, or blood collection tube.

A suction tool having a hollow handle and a probe extending from the handle near one end of the handle to define a lumen in fluid communication with the hollow handle and a fitting, formed to extend near the other end of the handle and shaped to receive a vacuum source drawing fluids through the probe, handle, and fitting. The handle also includes an aperture extending at an acute angle with respect to the axis of the handle.

A system and method are disclosed that track a deliverable to a user. The system includes an identifier or tag secured to the deliverable, a computer system for interrogating the identifier, and a personal device in communication with the computer system, wherein the personal device is held by the user at the time the user is administered the deliverable to detect the unique identity associated with the identifier device and confirms delivery of the deliverable to the user. The method includes attaching an identifiable tag that produces a unique signature to the deliverable, interrogating the tag at about the time of delivery to the user, and confirming that the user has been administered the deliverable through detecting the identifiable tag.

A system and method are disclosed that track a deliverable to a user. The system includes an identifier or tag secured to the deliverable, a computer system for interrogating the identifier, and a personal device in communication with the computer system, wherein the personal device is held by the user at the time the user is administered the deliverable to detect the unique identity associated with the identifier device and confirms delivery of the deliverable to the user. The method includes attaching an identifiable tag that produces a unique signature to the deliverable, interrogating the tag at about the time of delivery to the user, and confirming that the user has been administered the deliverable through detecting the identifiable tag.

An ear canal irrigator system having a hand-held spray bottle and a conduit tube connected to the spray bottle by a series of components that allow the tube to be connected without being screwed on and also prevents leakage of fluid. The system further includes an insertion tube connected to the conduit tube by a connecting piece having a splash guard, whereby the insertion tube is configured to be placed at or near the ear canal of a user. The insertion tube is shorter in length that the conduit tube and has a smaller diameter than the conduit tube so that when the fluid flows through the connecting piece into the insertion tube, the fluid has a more powerful fluid stream.

An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.