Various exemplary methods and devices (10, 110, 210) for delivering liquid therapeutic agents in solid tumors are provided. In general, a delivery device configured to deliver a liquid therapeutic agent into a solid tumor or other soft tissue can be configured to compress tissue and seal any fluid gaps around the delivery device during the delivery of the liquid therapeutic agent. In an exemplary embodiment the delivery device includes three elongate tubular shafts (12, 14, 16, 112, 114, 116, 212, 214, 216) configured to move longitudinally relative to one another. The elongate tubular shafts are configured to cooperate with one another to deliver the liquid therapeutic agent through a passageway of the delivery device to the solid tumor or other soft tissue and seal any fluid gaps around the delivery device while the liquid therapeutic agent is delivered into the solid tumor or other soft tissue.

An implantable medical instrument for use within a body includes a container that has an opening and holds a medicinal solution, and a soft portion that closes the opening. The medical instrument further includes a power receiver that receives power transmitted externally, and a light emitter that emits light by way of the power received by the power receiver. The light emitter includes at least one of a first light emitter that emits light having a center wavelength of 600 nm or more and 1100 nm or less, and a second light emitter that emits light having a center wavelength of 400 nm or more and 480 nm or less.

Disclosed are rapidly insertable central catheter (“RICC”) insertion assemblies and methods. For example, a RICC insertion assembly can include a RICC, an access guidewire, an introducer needle, and a coupler coupling the foregoing components together. The introducer needle can include a needle shaft and a sheath. The needle shaft can include a longitudinal needle slot. The sheath can seal the needle slot thereunder except for a sheath opening thereto in a proximal portion of the sheath. The coupler can include a coupler housing and a valve module disposed in the coupler housing. The valve module can seal the needle shaft and the sheath therein. The access guidewire can include a proximal end coupled to the coupler and a distal end disposed in the introducer needle, thereby enforcing a loop in the access guidewire. The RICC can be disposed over the loop in a ready-to-deploy state of the RICC insertion assembly.

Pigtail catheters and relates methods for measuring a pressure gradient across a bodily narrowing are disclosed. A pigtail catheter can comprise a proximal shaft segment and a distal shaft segment. The proximal shaft segment can include double lumen tubing defining a proximal pressure lumen and a non-coaxial, distal pressure lumen. In an example, the distal pressure lumen has a generally circular cross-sectional shape, and the proximal pressure lumen has a generally crescent or kidney cross-sectional shape that wraps partially around the distal pressure lumen. The distal shaft segment can include at least one distal orifice positionable distal to the bodily narrowing and at least one proximal orifice positionable proximal to the bodily narrowing. Each orifice can have a diameter of at least about 0.018 inches, for example. A manifold can be coupled to a proximal end of the proximal shaft segment and can include a proximal pressure port in communication with the proximal pressure lumen and a distal pressure port in communication with the distal pressure lumen.

A catheter assembly including a reinforcement structure and a catheter disposed over the reinforcement structure. The reinforcement structure includes a first outer wall reinforcement portion, a second outer wall reinforcement portion, and a septum reinforcement portion connecting the first outer wall reinforcement portion to the second outer wall reinforcement portion. The catheter includes a catheter outer wall and a catheter septum. The first outer wall reinforcement portion and the second outer wall reinforcement portion can be positioned at least partially in the catheter outer wall, and the septum reinforcement portion can be enveloped by the catheter septum. The catheter assembly can also include an outer tube disposed over the catheter and the reinforcement structure.

A rigidizing device includes an elongate flexible tube, a braid layer positioned over the elongate flexible tube, an outer layer over the flexible tube and the braid layer, and an inlet between the elongate flexible tube and the outer layer and configured to attach to a source of vacuum or pressure. The braid layer has a plurality of strands braided together at a braid angle of 5-40 degrees relative to a longitudinal axis of the elongate flexible tube when the elongate flexible tube is straight. The rigidizing device is configured to have a rigid configuration when vacuum or pressure is applied through the inlet and a flexible configuration when vacuum or pressure is not applied through the inlet. The braid angle is configured to change as the rigidizing device bends when the rigidizing device is in the flexible configuration.

A medical dispensing device which includes a catheter, an applicator tip at a distal end of the catheter, the catheter and the applicator tip defining a lumen having a longitudinal axis and a distal opening, a plunger in the lumen and movable along the longitudinal axis, and a plurality of elements in the lumen proximal to the distal opening and distal to the plunger, the plurality of elements stacked along the longitudinal axis for dispersement of one element at a time through the distal opening via a force applied by the plunger.

A device, method, and use of a device for temporary management of a wound, such as a wound in a heart. The device has a shaft, a blood flow blocking membrane at the first end of the shaft for blocking blood flow through the wound, and an abutment member that is mounted to the shaft and is axially movable along the shaft towards and away from the blood flow blocking membrane for abutting the wound and holding the blood flow blocking membrane adjacent the wound. The blood flow blocking membrane is resiliently flexible and movable between at least a first collapsed state for inserting the blood flow blocking membrane through the wound, and a deployed state for blocking blood flow through the wound.

Embodiments disclosed herein are directed to an anti-microbial coated urethral plug to reduce catheter associated urinary tract infections (“CAUTI”). A urethral plug is configured to engage a urinary catheter and includes a plug body defining a frustum shape, a lumen configured to receive the urinary catheter, and a slit extending longitudinally and extending from the lumen to a side surface of the plug body. The plug can further include one of a textured surface and a coating disposed on an outer surface and configured to mitigate microbial adhesion. A distal portion of the plug is configured to fit within a urethral opening to create a seal between the side surface of the plug body and the urethral opening. The urethral plug includes coatings, textured surfaces, or the like, and provides protection against the extra-luminal migration of microbes that may cause CAUTI.

Provided is a medical tubular body delivering device that is less likely to kink without reducing operability. The device has an outer tube through which the medical tubular body is disposed; a guidewire insertion member provided proximal to the medical tubular body; and an inner insertion member provided in the outer tube, and the guidewire insertion member has a penetration passage; a guidewire tube is provided in the penetration passage; the inner insertion member is partially fixed to the guidewire insertion member; a protection member is provided outside a part of the inner insertion member proximal to a fixing portion; the protection member has a reduced-area section where the protection member has a cross-sectional area in a cross-section perpendicular to an axis direction decreases towards a distal end; and the protection member in the reduced-area section is biasedly located against the guidewire tube with respect to the inner insertion member.