The present invention provides an automatic drug delivery device. The automatic drug delivery device includes an enclosure and a first piston disposed in the enclosure. The first piston partitions the enclosure to a first drug delivery chamber and a first expansion chamber. A first through hole and a second through hole are formed in the wall of the enclosure, the first through-hole communicates with the first drug delivery chamber, and the second through-hole communicates with the first expansion chamber. A first targeted dissolution membrane covers the first through hole and the second through hole, and dissolves at a first targeted region. A drug is filled in the first drug delivery chamber, and an expandable material is included in the first expansion chamber. The expandable material in the first expansion chamber can expand after absorbing liquid.

The present disclosure provides a gastroretentive drug delivery device having an expandable structure. The drug delivery device includes: a capsule body; an arm moving part movable within the capsule body; an elastic body positioned between one end of the capsule body and the arm moving part and acting to move the arm moving part toward the other end of the capsule body; an arm support part movable within the capsule body; a capsule cap configured to engage the other end of the capsule body; a rail formed within the capsule body; and an arm configured to be unfolded by longitudinal movement of the arm moving part and move along the rail. A disintegrable immediate-release formulation is positioned between the arm moving part and the arm support part. A disintegrable sustained-release formulation is positioned between the arm support part and the capsule cap.

An apparatus includes a chamber container and a tray. The chamber container has a first portion and a second portion removably coupled to the first portion. The first and second portions collectively define an inner volume. The tray is configured to be removably disposed within the inner volume of the chamber container. The tray includes a first portion and a second portion coupled to the first portion via a hinge. The first portion includes a first retention surface. The second portion includes a second retention surface. The tray is configured to receive a biodiffusion chamber between the first portion and the second portion such that the first retention surface and the second retention surface engage a portion of the biodiffusion chamber to (1) place the biodiffusion chamber in a predetermined orientation and (2) maintain the biodiffusion chamber in a substantially fixed position relative to the tray.

A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.

A device for removing earwax from an ear canal includes a shaft; and an earwax collector head at an end of the shaft. The collector head is in the form of a helical strip surrounding a substantially elongated space. The helical strip has a cross section such that an outward facing surface of the helical strip is substantially flat and an interior surface of the helical strip radially tapers to an inward facing edge. A distal end of the helical strip tapers to present a wedge.

A device for removing earwax from an ear canal includes a shaft; and an earwax collector head at an end of the shaft. The collector head is in the form of a helical strip surrounding a substantially elongated space. The helical strip has a cross section such that an outward facing surface of the helical strip is substantially flat and an interior surface of the helical strip radially tapers to an inward facing edge. A distal end of the helical strip tapers to present a wedge.

A dispenser device for delivering a composition into an anal or vaginal orifice includes an applicator having a shaft, one or more channels, and a plurality release ports. The shaft may extend from a tip to a base and have an outer surface. The plurality of release ports may be positioned along the outer surface of the shaft, and the one or more channels may extend through the shaft and be in fluid communication with the plurality of release ports.

A dispenser device for delivering a composition into an anal or vaginal orifice includes an applicator having a shaft, one or more channels, and a plurality release ports. The shaft may extend from a tip to a base and have an outer surface. The plurality of release ports may be positioned along the outer surface of the shaft, and the one or more channels may extend through the shaft and be in fluid communication with the plurality of release ports.

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

An implantable device comprising a nanochanneled membrane is described. The device uses nanofluidics to control the delivery of diagnostic and/or therapeutic agents intratumorally. The devices can be used for chemotherapy, radiosensitization, immunomodulation, and imaging contrast.