Some target anatomies within the ear, nose and/or throat of a patient may be difficult to access and treat. To provide a means of treating such target anatomies over time, drug delivery devices that are sized to be positioned within a naturally occurring or man-made anatomical cavity or passageway are preloaded with active agent(s). The drug delivery devices are affixed directly to, or in the vicinity of, a target anatomy. Once affixed, the drug delivery devices are configured to deliver active agent(s) at desired dosage(s) to the target anatomy through controlled elution of the active agent(s) as various structural features of the drug delivery devices are bio-eliminated.

Some target anatomies within the ear, nose and/or throat of a patient may be difficult to access and treat. To provide a means of treating such target anatomies over time, drug delivery devices that are sized to be positioned within a naturally occurring or man-made anatomical cavity or passageway are preloaded with active agent(s). The drug delivery devices are affixed directly to, or in the vicinity of, a target anatomy. Once affixed, the drug delivery devices are configured to deliver active agent(s) at desired dosage(s) to the target anatomy through controlled elution of the active agent(s) as various structural features of the drug delivery devices are bio-eliminated.

A device includes a shell including a proximal end and a distal end of the shell. The device also includes a plunger within the shell. The plunger can include a flexible stop at a proximal end of the plunger and a distal end. The device can further include an absorptive unit configured to absorb fluid within a vaginal cavity. The absorptive unit can be affixed to the distal end of the plunger. The absorptive unit can include an absorptive element affixed to a frame structure configurable to reversibly transition between a compressed and uncompressed configuration. The absorptive unit can also include a tether coupled to the absorptive unit via the frame structure. The tether can extend through the proximal end of the plunger. Related methods of use are also described.

Methods and compositions for delivering medicine and other substances to the brain and the body via the cribriform plate using foamable compositions are described. Methods and compositions for improving nasal hygiene and moisturizing the nasal cavity using foamable compositions are also described.

An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca.sup.2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca.sup.2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.

A modular, wearable sensor and drug administration device is disclosed. The device includes removable modules such as sensors and drug administration apparatuses within a single wearable device. The device may be comfortable and modules may be easily removed and replaced. The sensors and drug administration devices may be used in concert to monitor and administer drug to a patient. Such a device may improve a patient's quality of life.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

A delivery device may include a capsule housing, at least one tissue penetrating member in a sealed compartment in the capsule housing, wherein the at least one tissue penetrating member is configured to release a payload, and an actuator in the capsule housing and at least partially outside the sealed compartment, wherein the actuator is configured to advance the at least one tissue penetrating member out of the sealed compartment.

An ear drop applicator for the application of ear drops, which comprises a tray (3) for receiving a bottle of ear drops placed therein wherein the tray (3) comprises a spout (5) for inserting into an ear canal and through which the ear drops can pass from the bottle into the ear canal.