To provide a means which makes it possible to hold a microneedle array without an adhesive sheet and protect tips of microneedles. A foam support sheet for a microneedle array, which has an open cell surface on at least one side, the open cell surface being an arrangement portion for the microneedle array holding the microneedle array with a microneedle side of the microneedle array facing downward; as well as a microneedle array sheet consisting of a microneedle array and a foam support sheet, the foam support sheet having an open cell surface on at least one side, and the microneedle array being arranged on the open cell surface with a microneedle side of the microneedle array facing downward.

The disclosure relates to a flexible active species generator comprising: a first electrode of a conductive metal thin film; a second electrode of a ground electrode; a flexible dielectric layer of an insulator formed between the first electrode and the second electrode; and a plasma resistant functional layer formed between the dielectric layer and the second electrode, wherein the first electrode and the second electrode are electrically connected to an external power supply to generate an atmospheric pressure plasma to generate active species. The flexible active species generator has a plasma resistant function to prevent deformation and decomposition of an insulator caused by the plasma as well as an active species generating function from atmospheric pressure plasma, and has durability and safety, which is thus applicable to articles, foods, garments and human body in various forms.

A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.

Methods are provided that involve the intentional and controlled precipitation of a drug or active agent, or a reduction of solubility of a polymer or other film-forming component of a formulation, or a combination of both methods, to improve the processes for making microneedles or other objects by casting into molds and the resulting parts produced by casting. The selective reduction in solubility of formulation components solves many problems associated with the casting of polymer formulations into molds. The methods are preferably adapted for making microneedles of biodegradable polymer and drug composites, and may also be used to produce other solid objects formed by casting into molds of compositions containing polymers and active agents.

A tattoo machine includes a tubular housing and an electromagnetic assembly disposed in the tubular housing. The electromagnetic assembly includes a first through-hole extending axially therethrough. A magnet unit is disposed in the first through-hole and includes a second through-hole extending axially therethrough. A core bar extends through the second through-hole and includes a tattoo needle on an end thereof. The tattoo needle can be actuated by the magnet unit to an exposed position outside of a bottom end of the tubular housing. An electric power transmission unit is electrically connected to the electromagnetic assembly. The electric power transmission unit can be in electrical connection with a power grid or a power supply and can output alternating current to the electromagnetic assembly.

Drug delivery systems and wearable articles including the drug delivery systems are provided. The drug delivery systems may include a substrate coated with at least one polymer and at least one active compound. The substrate is operable to include yarns, yarn precursors, threads, filaments, fibers, and/or other suitable substrates. Methods for manufacturing drug delivery systems are also provided. The methods are operable to include disposing a solution including a monomer and an active compound on the substrate. The methods are also operable to include exposing the solution and the substrate to UV light to initiate polymerization of the solution.

Drug delivery systems and wearable articles including the drug delivery systems are provided. The drug delivery systems may include a substrate coated with at least one polymer and at least one active compound. The substrate is operable to include yarns, yarn precursors, threads, filaments, fibers, and/or other suitable substrates. Methods for manufacturing drug delivery systems are also provided. The methods are operable to include disposing a solution including a monomer and an active compound on the substrate. The methods are also operable to include exposing the solution and the substrate to UV light to initiate polymerization of the solution.

This disclosure sets forth various systems and methods for deploying anchored medical devices within a human or animal. The medical devices may deliver payloads, such as various sensors, electrodes, transmitters, cameras, electrical or other interventional devices, drugs or therapeutics. The devices may have one or more anchors, which attach the device to an anatomy of interest. This allows for methods and processes to be performed over periods of time, such as extended delivery of a therapy or real time sensing of characteristics inside a body, which the device remains within a given location.

Embodiments of an apparatus include a needle cartridge configured to attach to and interface with an actuating device. The needle cartridge includes a housing, a needle group assembly, and a fluid port. The housing forms a cavity and includes a first aperture and a second aperture opposite the first aperture. The needle group assembly includes a needle and a needle holder. The needle group assembly is configured to move in a reciprocating motion relative to the housing along an axis from the first aperture to the second aperture. During the reciprocating motion, the needle fully retracts into the cavity through the first aperture. The fluid port is integrated with the housing and includes a hollow projection forming a conduit and extending away from the housing. The fluid port includes a third aperture, wherein the fluid port is configured to interface with a fluid delivery system.

A catheter for ultrasonic-driven bladder therapeutic agent delivery, including: a tube having a proximal expandable portion and a distal end, and at least one transducer sleeve accommodating at least one ultrasound transducer mounted on the tube between the proximal expandable portion and the distal end.