A transdermal delivery device for dispensing personalized transdermal dosage formulations from a plurality of reservoirs, and a personalized method for producing the transdermal delivery device. A prescription fill service receives electronic prescription data for a plurality of transdermal dosage formulations to be administered to a given patient. The prescription fill service deposits transdermal dosage formulations in two or more reservoirs of a transdermal device substrate via 3D printing of printable pharmaceutical agent. The electronic prescription data may include transdermal dosage formulations data used to select printable pharmaceutical agent deposited in respective reservoirs. The electronic prescription data further may include medication regimen data for administration of transdermal medications, such as timing data for release of selected transdermal dosage formulations. In an embodiment, a finished transdermal delivery device includes barriers formed at reservoir openings, a controller, and a controlled energy source that degrades the barriers to actuate release of reservoir contents.

It is provided a method and devices for detecting kidney failure and dialysis of a subject wherein the epidermis is irreversibly electroporated without generating any heat and a negative pressure is applied forming micro-conduits in the epidermis from which the interstitial fluid can be extracted, analysed and filtered to produce for example a dialysate and returned to the subject.

The present invention relates to a vaginal drug delivery device configured to safely and effectively deliver a therapeutic formulation in the vagina at or near a desired target area for a specified time period.

Tattoo machines configured to drive a needle towards a marking area. The tattoo machines include a motor, a first arm, a second arm, and a primary spring. The first arm is operatively connected to the motor and driven by the motor towards the marking area. The second arm is spaced from the first arm and configured to couple to the needle. The primary spring is biased to move the first arm and the second arm away from the marking area. The second arm is driven towards the marking area when the first arm is driven towards the marking area by the motor.

A kit to facilitate creation of and compliance with a personalized injection site rotation plan includes a plurality of disposable injection devices adapted for giving an injection of a medication to a patient in need thereof, each disposable injection device having a permanent, distinctive mark that may be the same as or different from the distinctive mark on other disposable injection devices in the kit; and a plurality of user-defined association tools, wherein for each unique distinctive mark on a disposable injection device, at least one user-defined association tool has a distinctive mark that corresponds to the unique distinctive mark.

A catheter comprises an elongated carrier and a balloon carried by the carrier in sealed relation thereto. The balloon has an outer surface and is arranged to receive a fluid therein that inflates the balloon. The catheter further comprises a shock wave generator within the balloon that forms mechanical shock waves within the balloon, and a medicinal agent carried on the outer surface of the balloon. The medicinal agent is releasable from the balloon either before or in response to the shock wave.

Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.

The invention discloses a cardiac pacemaker, characterized in that the cardiac pacemaker comprises a multiple of microneedles and a chip comprising at least one comparator with adaptive level, sequence control circuit, at least one capacitor stack built by n capacitors and 2n switches, at least one buffer capacitor outside the at least one capacitor stack, at least two additional switches outside the at least one capacitor stack, a CMOS-Logic, wherein further, the cardiac pacemaker comprises an interposer layer comprising holes for the multiple of microneedles and a lid. The cardiac pacemaker is characterized in that the chip, is located on one surface of the interposer layer and that the lid and the interposer layer form a capsule for the chip. Further, each microneedle of the array of microneedles has a distal end which protrudes from the chip and the cardiac pacemaker is adapted to be electrically self-sufficient.

A transfer device for a living organism for placing an object in a living organism comprises a plurality of movable units. Each movable unit comprises one or more needles extending in a first direction. Each needle has a cylindrical shape capable of storing the object therein. Each movable unit is movable in the first direction.

A method and an system for vaccinating a mammalian subject. The method includes the steps of: arranging a source of electromagnetic radiation proximate to a target zone of skin of the mammalian subject; controlling the source of electromagnetic radiation to deliver a dose of electromagnetic radiation to the target zone determined to create one or more thermally-denatured zones in the target zone; and intradermally injecting a vaccine within the target zone to vaccinate the mammalian subject. The system for vaccinating a subject may include an electromagnetic radiation source configured to be arranged proximate to a target zone on an exterior of the subject; a user control configured to selectively cause the electromagnetic radiation source to deliver a dose of electromagnetic radiation toward the target zone to create one or more thermally-denatured zones in the target zone; and a vaccine-delivery system configured to deliver a vaccine to the target zone.