An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

A mask according to an embodiment comprises: a body having a shape corresponding to a user's face; a first recess disposed on one surface of the body, opposite to the user's face; and a piezoelectric part disposed in the first recess, wherein the first recess has a shape recessed outward from the one surface of the body and is disposed in a region corresponding to at least one of the user's brow region and eye rim regions, and the piezoelectric unit protrudes beyond the one surface toward the user.

The present invention provides a method for treating a skin neoplasm in a subject, comprising administering to the subject's skin a composition comprising an effective amount of one or more antineoplastic agents, wherein the composition is administered with a microneedle delivery device.

The present invention provides a method for treating a disease or condition in a subject, comprising administering to the subject's skin a composition comprising an effective amount of exosomes, wherein the composition is administered with a microneedle delivery device.

The present invention is directed to an applicator, configured to reversibly attach to a dispensing device, with at least one micropore and a kit for administration of a therapeutic agent. Methods of use of the applicator are also disclosed herein.

Presented herein are techniques for localized release of systemically circulating therapeutic substances, which combine many of the advantages of systematic and localized administration, while eliminating many of the associated drawbacks. More specifically, in accordance with the techniques presented herein, an electro-responsive biomaterial is systemically administered to a recipient of an electrically-stimulating implantable medical device. The electro-responsive biomaterial comprises a therapeutic substance that is only activated (e.g., released) in the presence of an electromagnetic field generated by the electrically-stimulating implantable medical device.

A material includes a metallic, nanoporous structure having a plurality of nanopores having a porosity that allows passage of insulin but not IgG. The metallic nanoporous structure includes titanium, 316L stainless steel and may have a textured nano-sericeous surface. A nanoporous bicontinuous structure can be integrated with nanopores.

A medical fluid therapy system having a multi-state alarm feature is disclosed. An example medical fluid therapy system includes a pumping apparatus configured to pump a medical fluid from a fluid container. The example system also includes a processor configured to generate a first alarm signal associated with a first low level event of the medical fluid in the fluid container, generate a second alarm signal associated with a second low level event of the medical fluid in the fluid container, and receive an activation of a snooze element for deactivating the first alarm signal after the first low level event has occurred and enabling the second alarm signal to be activated upon occurrence of the second low level event. The system further includes a server configured to receive and route at least one of the first alarm signal or the second alarm signal for display at a user device.

Gas recirculation systems for use in endoscopic surgical procedures including a gas recirculation pump are disclosed. The gas recirculation pump may work in conjunction with an insufflator used to inflate a patient's peritoneal cavity during surgery. The gas recirculation system may recirculate a high flow rate of gas from and to the patient while filtering particulate matter out of the gas and while maintaining an adequate moisture content in the gas. The gas recirculation pump may include a disposable pump cartridge releasably connected to a pump motor. A controller may detect a fault or safety condition in the gas recirculation system based on the load placed on the pump motor.

Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.