Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.

Described are surgical tools to facilitate the proper implantation beneath the outer layer of tubular anatomical structures, or ductus, to include vessels, the trachea, esophagus, gut, and ureters, as well as the outer layer or within the parenchyma of organs, glands, or other tissue, of medicinal, magnetically susceptible, magnetized, and/or radiation-emitting spherules sized in proportion to the substrate structure. Spherule insertion tools expedite insertion transluminally to implant the wall surrounding a lumen making possible therapy and/or extraluminal stenting which leaves the lumen clear for subsequent passage. Spherules can also be introduced into deeper tissue through a ‘keyhole’ incision at the body surface. For evolving methods calling for the placement of numerous ‘seeds’ and/or boluses, eliminated are the need for more extensive incision with increased trauma, procedural duration, and healing time. Avoidance of the lumen is augmented by placing the magnets subcutaneously rather than using a magnetized perivascular collar, or stent-jacket.

A skin treatment device includes a control unit and a hand tool. The hand tool includes a body, a wiper head, and a needle roller head. The wiper head includes a rotatable wiper structure including one or more wiper blades. The needle roller head includes needle roller structure. The skin treatment device provides a multi-step process including desincrustation, skin transdermal delivery of topical agents, serums, and the like, microdermabrasion, and fractional micro-channeling application.

A pellet having a convex shaped front includes a plurality of radially disposed surface slots. The concave shaped rear portion has a matching number of surface ribs that can be frictionally attached to the convex portion's slots. The pellet is constructed of a combination of medical compounds along with appropriate binders and other compounds that are pressed together under high pressure to produce a rigid mass capable of being propelled at high speeds and to pierce the skin of an animal or person where the compounds can be dissolved when contacting the internal liquid portion of the animal or person. The pellet can be loaded and propelled by a standard air rifle, gun, or pistol.

Apparatus and methods are provided for delivering fluids into a patient's body that includes a tubular member including a proximal end, a distal end sized for introduction into a patient's body, and a fluid delivery lumen extending between the proximal and distal ends; and a flexible pad on the distal end including a tissue contacting surface, a passage communicating with the fluid delivery lumen, and plurality of capillary channels in the tissue contact surface communicating with the passage, the capillary channels configured to deliver fluid from the fluid delivery lumen and passage to tissue contacted by the tissue contact surface.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

The invention relates to a drive device for a hand-held device (1) for locally puncturing a skin, having a housing (5) which is connectable to a module housing (8) of a skin-puncturing device; and an electrical drive device which is arranged in the housing (5) and has a tapping component which is designed to provide a tap for tapping a rotary drive movement generated by the electric drive device for the skin-puncturing device. The electric drive device has an electric motor designed as an external rotor with a rotating rotor component, in which the tapping component is arranged on the rotor component and eccentrically in relation to a rotor axis. Furthermore, a hand-held device (1) for locally puncturing a skin is provided.

Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.

A method for delivering therapeutics includes infusing a hydrogel with cannabis; and contacting the hydrogel infused with cannabis into a human which causes the controlled timed releasing of the cannabis with hydrophobic molecules to permeate through a lipid pathway.

A device includes a cartridge to contain a CBD or CGB solution; a laser or heat source coupled to the cartridge to release the CBD or CBG solution; and a variable voltage power source coupled to the laser or heat source to adjust heating temperature on the cartridge.