Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

An implantable drug delivery device and method for delivering a drug to a living body. The device includes a housing having at least one opening, a reservoir within the housing adapted to contain a drug, a temporary seal closing the opening of the housing, and a heating element in thermal contact with the temporary seal. The heating element is adapted to generate heat in response to a magnetic field to melt the temporary seal and release a drug within the reservoir through the opening of the housing.

Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

Disclosed herein are methods, devices, and systems for evaluation, diagnosis, prevention, and treatment of peripheral neuropathies.

Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 μm or more and 2000 μm or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.

Methods, devices and systems for delivery of an anti-PD-1 or an anti-PD-L1 therapeutic agent to the lymphatic system for treating cancer in a patient are described.

This application relates to a wearable multi-shot injection patch. In one aspect, the patch includes a base that has a bottom surface and a top surface and is configured so that the bottom surface is disposed against a patient's skin. The patch may also include a first container that is supported by the base and accommodates a first drug, and a second container that is supported by the base and accommodates a second drug. The patch may further include a first pyrotechnic charge disposed between the top surface and the first container inside the base, and a second pyrotechnic charge disposed between the top surface and the second container inside the base. The patch may further include one or more electronic components configured to detonate the first pyrotechnic charge and the second pyrotechnic charge.

A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.

Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.