In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated travelers diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal. The invention also provides devices for delivering a fecal material to a patient.

A medical device configured to restrict medicament dispersion within a cerebrospinal fluid flow of the patient. The medical device including an implantable catheter having a distal end configured to be positioned within a flow of the cerebrospinal fluid, a proximal end, a body defining a lumen extending lengthwise along the implantable catheter configured to enable a flow of medicament from the proximal end to an infusion port located in proximity to the distal end, and a contoured surface defined by an exterior of the body in proximity to the infusion port configured to inhibit dispersion of the medicament within the cerebrospinal fluid.

The present disclosure relates to a connector device for a negative pressure wound therapy system having a connector housing, a fluid outlet connected to the connector housing, an air feeding port and an air filter and coupling means. The fluid outlet is adapted to be connected to a negative pressure source. The connector device is adapted to be engaged with a wound side connector of a wound side assembly by means of the coupling means. The wound side assembly includes a fluid removing conduit and an air supplying conduit, wherein a portion of each one of the fluid removing conduit and the air supplying conduit is connected to the wound side connector. The connector device when engaged with the wound side connector, the fluid removing conduit is fluidly connected to the fluid outlet and the air supplying conduit is fluidly connected to the air feeding port such that air ambient of the connector device can be fed to the air supplying conduit via the air feeding port and the air filter.

Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

Valve assemblies having improved ability to selectively control flow of fluids through the catheter and prevent leakage of fluids from the proximal end of a catheter that is positioned within a patient. Such improved catheter valve assemblies also prevent leakage of fluids after repeated insertion and removal of medical instruments through the valve.

A cleaning catheter (200) insertable into a tracheal ventilation tube (160) and an input module (156) are provided for use with a suction source (601), the input module (156) coupled to the cleaning catheter (200) and including (i) an inflation module (330), including an inflation chamber (335) separate from the suction source (601); (ii) a flow regulator (700), configured to assume first and second fluid-control states; and (iii) a mechanical user control element (320), which is configured (a) to mechanically and non-electrically set the fluid-control states, (b) to assume first and second configurations, and (c) to mechanically and non-electrically increase pressure in an interior of an inflation chamber (335) during a transition of the mechanical user control element (320) from the first configuration to the second configuration. The flow regulator (700), when in the first fluid-control state connects the suction source (601) and an interior of an inflatable element (588) of the cleaning catheter (200) in fluid communication to deflate the inflatable element (588).

A cleaning catheter (200) insertable into a tracheal ventilation tube (160) and an input module (156) are provided for use with a suction source (601), the input module (156) coupled to the cleaning catheter (200) and including (i) an inflation module (330), including an inflation chamber (335) separate from the suction source (601); (ii) a flow regulator (700), configured to assume first and second fluid-control states; and (iii) a mechanical user control element (320), which is configured (a) to mechanically and non-electrically set the fluid-control states, (b) to assume first and second configurations, and (c) to mechanically and non-electrically increase pressure in an interior of an inflation chamber (335) during a transition of the mechanical user control element (320) from the first configuration to the second configuration. The flow regulator (700), when in the first fluid-control state connects the suction source (601) and an interior of an inflatable element (588) of the cleaning catheter (200) in fluid communication to deflate the inflatable element (588).

A medical device includes: a medicinal agent storage device connected to the catheter, a flow control device, and a package. The medicinal agent storage device includes a storage part and a second channel, the storage part is configured to store a medicinal agent, and wherein the second channel provides fluid communication between the storage part and the first channel. The package encloses the catheter, the medicinal agent storage device, and the flow control device in a sterilized state. In a first state, the flow control device is configured to prevent the medicinal agent from flowing from the storage part into the first channel. The flow control device is included in the catheter or included in the medicinal agent storage device.

A cannula system is provided. The system may comprise: a cannula having a hose element having front and rear end regions, wherein a channel extends from the front end region to the rear end region, a hollow body having a front end region, and a connector which, in a connected state of the cannula system in which the front end region of the hollow body is introduced into the channel of the hose element, receives the front end region of the hose element and the front end region of the hollow body in an inner region of the connector. The connector may exert clamping forces on the front end region of the hose element and clamp the front end region of the hose element between the front end region of the hollow body and the connector. Also provided is a blood pump system including such a cannula system.

A cannula system is provided. The system may comprise: a cannula having a hose element having front and rear end regions, wherein a channel extends from the front end region to the rear end region, a hollow body having a front end region, and a connector which, in a connected state of the cannula system in which the front end region of the hollow body is introduced into the channel of the hose element, receives the front end region of the hose element and the front end region of the hollow body in an inner region of the connector. The connector may exert clamping forces on the front end region of the hose element and clamp the front end region of the hose element between the front end region of the hollow body and the connector. Also provided is a blood pump system including such a cannula system.