A skin patch drug infusion device includes an infusion mechanism module, a driving unit, a power unit, a control mechanism module, a blockage detection module and an adhesive patch. The infusion mechanism module includes a reservoir used for accommodating the drug to be infused, a screw and a piston connected with the screw arranged inside. The driving unit is provided with driving wheel and driving end. The driving wheel is connected with the screw, and the driving end pushes the driving wheel to make the screw advance in the reservoir. The power unit connected with the driving unit is used for offering power for the driving unit. The control mechanism module is electrically connected with the infusion mechanism module. The blockage detection module operably connected to the control mechanism module includes a detection circuit and at least one detection element.

A skin patch drug infusion device includes an infusion mechanism module, the infusion mechanism module includes: an upper case, a lower case, and a frame. The upper case is provided with multiple upper case engaging portions, and the lower case is provided with multiple lower case engaging portions, the frame is provided with multiple frame engaging portions engaged with the upper case engaging portions and lower case engaging portions; the lower case is further provided with a circuit board, while the circuit board is provided with a plurality of specific connection ends; the frame is provided with electrical connection terminals of specific components, and electrically connected the specific electrical connection ends on the circuit board to realize the internal circuit conduction of the infusion mechanism module. A control mechanism module, is electrically connected with the infusion mechanism module to regulate drug infusion.

A skin patch drug infusion system includes an infusion mechanism module. The infusion mechanism module includes: a reservoir with a drug inlet and a drug outlet for accommodating the drug to be infused; an infusion needle with one end connected to the drug outlet of the reservoir. The other end is inserted subcutaneously implanting drug infusion. The skin patch drug infusion system includes: a control mechanism module, which works collaboratively with the infusion mechanism module to regulate drug infusion; an adhesive patch that attaches the infusion mechanism module and/or the control mechanism module to the skin surface; a filling module. The drug to be infused into the reservoir is filled via the drug inlet, the volume of the filling module is deliberately designed to be greater than the volume of the drug to be infused to ultimately reduce the risk of air being injected into the body.

An assembly for promoting interstitial fluid flow can include an implant having first and second electrodes, a control unit, and one or more magnets. The implant can be disposed at a selected site of a subject, and the control unit can be electrically coupled to the first and second electrodes and can provide power to the first and second electrodes to generate an electric field at the selected site. The one or more magnets can be disposed adjacent to the selected site and can generate magnetic field in a direction orthogonal to the electric field in order to drive electrically conductive interstitial fluid flow at the selected site.

An assembly for promoting interstitial fluid flow can include an implant having first and second electrodes, a control unit, and one or more magnets. The implant can be disposed at a selected site of a subject, and the control unit can be electrically coupled to the first and second electrodes and can provide power to the first and second electrodes to generate an electric field at the selected site. The one or more magnets can be disposed adjacent to the selected site and can generate magnetic field in a direction orthogonal to the electric field in order to drive electrically conductive interstitial fluid flow at the selected site.