Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

A method of manufacturing a cartridge is described. An injection needle is inserted into a mold that forms a barrel. The barrel defines an open proximal end, an opposing distal end, an internal reservoir therebetween, and an arm projecting distally from the distal end of the barrel and having a portion bent at a fixed angle. The injection needle is positioned within a portion of the mold configured to form the arm of the barrel, and a terminal needle tip is oriented such that a beveled opening of the needle tip is distally facing. The injection needle is stabilized against movement with a gripping device. The mold is filled with resin to form the barrel around the injection needle. The gripping device is separated from the injection needle upon hardening of the resin.

An apparatus and method are provided for administering an inhaled drug to a person while simultaneously administering oxygen from a medical oxygen mask. The inhaled drug is from a pressurized metered dose inhaler (MDI), employing an extender tube about 3-10 cm long that fits into or over the mouthpiece of the inhaler. The MDI with extender tube is inserted into the mask and positioned so that the plume of drug travels through the extender when the MDI is actuated and is directed to just inside the mouth of the person. In an embodiment, an exhalation filter is provided to prevent contamination from infectious agents in the exhaled air from the person.

A patient interface can have features improving the comfort of use by reducing the perceived pressure of a nose-contacting cushion of the patient interface against the nose. The patient interface can have rigid headgear connection elements connectable to a frame of the respiratory interface. The rigid headgear connection elements can be shaped to reduce the force of the cushion against the nose. Headgear for a patient interface can also have features improving the stability of headgear of the head. The headgear can have a relatively rigid framework and a relatively pliable overlay covering the framework. The framework can have apertures defining a front portion to be positioned below or near the cheekbones, a rear portion to be positioned over the sides of the head around the ears, and a top portion to extend upward along the head towards the crown.

Ventilation masks are disclosed herein including a mask body and a gas manifold coupled to the mask body to form a gas channel for directing a gas through a gas port to create a curtain effect gas flow within the patient cavity and form a gas curtain within the patient cavity and adjacent to at least one vent opening formed through the mask body, and a sampling cover couplable with the mask body to form a sampling channel between a sampling portal of the sampling cover and a sensing port, where the sampling portal is formed by a protrusion of the sampling cover that extends into the vent opening and can extend toward a patient cavity formed by an inner surface of the mask body.

A capsule article (100) includes a polymeric body (110) extending along a longitudinal axis from a first end to a second end and defining a capsule cavity (105) containing powder, and a metal foil (120) and a sealant layer (130) covering an outer surface of the polymeric body. A method of forming a hermetic capsule includes the steps of wrapping a capsule, with a metal foil; and enclosing the capsule with a sealant layer to form a hermetic barrier enclosing the capsule.

The invention relates to a piston stopper (10) for a medical syringe (1) wherein the piston stopper (10) has an end wall (11), a lateral wall (12) and an internal thread (16) for securing a piston rod (7). The piston stopper (10) comprises a main body (10a) which made of a cycloolefin, in particular a cycloloefin copolymer or a cycloolefin polymer. A plurality of sealing rings (13a-13d) that are made from a plastic material extend around the main body of the piston (10) and are materially bonded to the main body of the piston (10a). The invention furthermore relates to a medical syringe (1) and to a method for the production thereof.

An apparatus for humidifying a flow of breathable gas includes a water reservoir and a water reservoir dock forming a cavity structured and arranged to receive the water reservoir in an operative position. The water reservoir comprises a reservoir base including a cavity structured to hold a volume of water, the reservoir base including a main body and a thermally conductive portion provided to the main body. The thermally conductive portion comprises a combined layered arrangement including a metal plate and a thin film, the thin film comprising a non-metallic material and including a wall thickness of less than about 1 mm. The thin film is adapted to form at least a bottom interior surface of the water reservoir exposed to the volume of water, and the metal plate is adapted to form a bottom exterior surface of the water reservoir.

The passive safety device comprises a sleeve having a proximal end configured to be secured to a distal tip of the injection device, a hub slidably mounted onto the sleeve between a pre-use position, an injection position wherein the hub is proximally located with regard to the pre-use position, and a safety position wherein the hub is distally located with regard to the injection position, a biasing element configured to urge the hub distally towards the safety position, and a protector configured to slide together with the hub relative to the sleeve between the pre-use position and the injection position. The safety device further comprises first blocking means configured to block a distal movement of the protector when the hub is in the injection position so that the protector is prevented from sliding back together with the hub in a distal direction.

An extracorporeal blood treatment module includes a plurality of gas transfer units, having a first polymer layer with a plurality of gas channels, a second polymer layer with a plurality of blood channels, and a gas permeable membrane disposed between the plurality of gas channels and the plurality of blood channels, a fluid transfer unit integrated with the plurality of gas transfer units, and including a third polymer layer having a plurality of fluid collection channels, a fourth polymer layer having a plurality of blood channels, and a fluid permeable membrane disposed between the plurality of fluid collection channels and the plurality of blood channels, and a housing containing the plurality of gas transfer units and fluid transfer unit.