A vaporizer system may include a vaporizer device and a vaporizer accessory configured to couple to the vaporizer device. The vaporizer accessory may include a sensor configured to continuously and passively monitor a biomarker of the user. The biomarker includes a concentration of carbon monoxide in the user's blood. Related systems and methods are also described.

Certain pet products, such as collar, halters, pet beds, and the like, may be adapted to provide transcutaneous vibratory output. A device adapted to be worn by a non-human animal may include i) at least one of a collar or a harness structured to fit the non-human animal; and ii) at least one transducer located at least partially within the at least one collar or harness and structured to deliver a transcutaneous vibratory output to the non-human animal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity.

A therapy system configured to wash out or flush out the oral and/or nasal cavity to reduce the effective dead space and reduce the work of breathing. The system may displace the expired air in the oral and/or nasal cavity with atmospheric air, or air with altered concentrations, for example, increased humidity, or oxygen levels. A sealed oral interface is provided to the mouth of a patient to supply a volume of pressurized gas. A control system to synchronize the supply of pressurized gas with the patients respiratory cycle. The supply of respiratory gas may be provided during only a portion of the respiratory cycle.

A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.

The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.

Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

The application is directed to a mesh nebulizer and related system including a dosing unit for providing a predetermined amount of a therapeutic agent, wherein the therapeutic agent is delivered in a portion container to be opened by pressure. The dosing unit comprises an uptake chamber with a dosing opening for dispensing the therapeutic agent, an opening for inserting a portion container and a locking body for the opening. The locking body is adapted to be moved from an open position in which the locking body releases the opening to a closed position in which the locking body closes the opening. The locking body is further adapted to be moved from the closed position to a drainage position in which the locking body applies pressure to the portion container to open the portion container and release the therapeutic agent.

A ureteral catheter is provided, including a drainage lumen including a proximal portion and a distal portion configured to be positioned in a patient's kidney, renal pelvis, and/or in the ureter adjacent to the renal pelvis, the distal portion including a retention portion for maintaining positioning of the distal portion of the drainage lumen, the retention portion including at least two openings on a sidewall of the retention portion for permitting fluid flow into the drainage lumen wherein a total area of a proximal most opening of the at least two openings is less than a total area of more distal opening(s) nearer to the distal end of the drainage lumen, and wherein when negative pressure is applied through the ureteral catheter, fluid is drawn into the ureteral catheter through the at least two openings.

Certain embodiments provide systems, methods, and computer program products that administer pain management treatments remotely, according to a dynamic prescription. In some embodiments, the dynamic prescription provides for changes in a dosage of a medication or electrical stimulation, based for instance upon changes in the patient's pain tolerance level, biological indicators, or behavioral characteristics. In some embodiments, if it is determined that a dosage change is needed, the dosage change can be compared against the dynamic prescription to determine whether the dosage change is permitted within the scope of the dynamic prescription. In some embodiments, if the dosage change is determined to be outside what is permitted by the scope of the dynamic prescription, the updated dosage information can be provided to the patient's physician for authorization of the updated dosage.

Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.