A method for removing excess fluid from a patient with hemodilution is provided. The method includes: deploying a urinary tract catheter into the patient such that flow of urine from the ureter and/or kidney is transported within a drainage lumen of the catheter; applying negative pressure to the ureter and/or kidney through the drainage lumen of the catheter to extract urine from the patient; periodically measuring a hematocrit value of the patient; and if the measured hematocrit value is greater than a predetermined threshold value, ceasing the application of the negative pressure to the ureter and/or kidney. A system for removing excess fluid from a patient with hemodilution including a ureteral catheter and a pump is also provided.

A method of navigating and positioning an endovascular device in a vasculature is disclosed. Initially, a system including an endovascular device and at least one transducer is inserted into the lumen of a patient. An acoustic signal is then transmitted within the lumen. A reflected signal is pre-processed to extract one or more acoustic features. The one or more acoustic features are processed using a computer readable set of rules to produce an output related to guidance of the instrument within a blood vessel or a position of the instrument within the blood vessel.

A method of ventilator control that includes receiving machine data from a mechanical ventilator and detecting one or more clinical events in the received machine data. The method further includes evaluating the machine data within the detected one or more clinical events for compliance with lung protective ventilation (LPV) recommendations. The method further includes at least one of producing a visual indication or a graphical display of the evaluated compliance with the LPV recommendations and controlling the mechanical ventilator based on the evaluated compliance with the LPV recommendations.

Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

The wound treatment apparatus combines an internal negative pressure (vacuum) pump and an internal positive pressure (compressor) pump connectable to an external oxygen supply for providing both negative pressure wound therapy and hyperbaric oxygen wound therapy to a wound site. The apparatus also includes a user interface operatively connected to an electronic controller that monitors and actuates the vacuum and compressor pumps. The user interface and controller enables the apparatus to provide multiple modes of operation and the ability to selectively change between negative pressure therapy operational modes and hyperbaric oxygen operational modes.

A system includes: a robot comprising an arm, the arm comprising a flange, the flange coupled to an end of the arm, the arm configured to move the flange along a degree of freedom; a mask coupled to the flange, the mask configured to deliver gas to a user, wherein the arm further comprises a kinematic mount, the kinematic mount usable to do one or more of orient and locate the mask with respect to the flange; a ventilator coupled to the mask, the ventilator configured to deliver the gas to the mask; a gas tube coupled to both the mask and the ventilator, the gas tube configured to carry gas between the ventilator and the mask; and a tracking system, the tracking system configured to capture image data of one or more of the mask and a face of the user.

Delivering vibratory therapy to a user may include using a system with a first transducer adapted to emit a first transcutaneous vibratory output; a second transducer adapted to emit a second transcutaneous vibratory output; and a processor in electronic communication with a user interface, the first transducer, and the second transducer, wherein the user interface accepts a user target state. The processor may be programmed to (i) generate a first transcutaneous vibratory output pattern comprising a first perceived pitch, a first perceived beat, and a first intensity; (ii) generate a second transcutaneous vibratory output pattern comprising a second perceived pitch, a second perceived beat, and a second intensity; (iii) cause the first transducer to emit a first transcutaneous vibratory output based on the first transcutaneous vibratory output pattern; and (iv) cause the second transducer to emit a second transcutaneous vibratory output based on the second transcutaneous vibratory output pattern.

An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

A method includes: obtaining a desired value for a parameter relevant to the automatic delivery of breathable gas; saving, by the system, the desired parameter value; finding, by the system, an actual value of the parameter; querying, by the system, whether the actual parameter value agrees with the desired parameter value; determining, by the system, that the actual parameter value does not agree with the desired parameter value; adjusting, by the system, a system setting so as to attain the desired parameter value; querying, by the system, whether the actual revised parameter value agrees with the desired parameter value; and repeating, by the system, the steps of determining, adjusting, and querying whether the actual revised parameter value agrees with the desired parameter value until the actual revised parameter value agrees with the desired parameter value.

An implantable emergency management drug delivery system configured to deliver a medicament to reverse the effects of a drug overdose. The implantable emergency management drug delivery system including an implantable infusion pump configured to infuse a first medicament, and an emergency handling device having at least one physiological sensor configured to monitor a condition of a patient for a possibility of an overdose from the first medicament, a communication module configured to communicate the possibility of an overdose to the implantable infusion pump, and an implantable medicament delivery mechanism configured to deliver a second medicament to reduce one or more adverse physiological effects of the first medicament.