A method of treating a bone defect is provided. The method comprises administering to the bone defect an amount of about 0.1 μg to about 800 μg of growth differentiation factor 5 (GDF-5) over a period of at least three days. An implantable matrix for treating a bone defect is also provided.

A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.

A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature or fluid flow of air flow in a nasal or oral cannula, mask or helmet.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

A mask system includes a cushion for a mask that seals at its upper extent in a region of the nose that is generally above the tip of the nose or pronasale, and extends across a portion of the cartilaginous framework, alar or flares of the patient's nose, e.g., not extending over or across the nasal bone of the patient's nose.

The invention relates to a dart (10) comprising a body, the body defining a chamber (24) having a plunger located therein to operatively deliver a substance through a hypodermic needle (32) extending through a front end of the body, and a retainer comprising a barb body locatable on the hypodermic needle (32) characterised in that the barb body is threaded. The invention further relates to a dart retainer, wherein the retainer comprises of a threaded barb body locatable on a hypodermic needle (32) of a dart (10).

The present teachings generally include parabiotic dialysis systems and techniques. For example, the present disclosure includes parabiotic liver dialysis, e.g., for use in settings with limited resources. To this end, a parabiotic liver dialysis system may include a device having a semipermeable membrane with an average pore size that allows for the passage of albumin therethrough. In such a system, a first extracorporeal circuit may connect the device to the vascular system of a first animal (e.g., a liver patient), and a second extracorporeal circuit may connect the device to the vascular system of a second animal (e.g., a human with normal liver function), where the exchange of albumin therebetween is facilitated through the device. The present disclosure also includes various safety measures for parabiotic dialysis systems and techniques, such as biometric verification systems and techniques.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

Disclosed devices for injection of medicament to a subject can include a hand-held unit, at least one control unit, and one or more medicament chambers fluidly coupled to the control unit. The hand-held unit having a head portion and a body portion, the head portion comprising at least one needle and a movable head, the movable head being axially movable relative to the body portion between an extended position and a retracted position. The control unit being fluidly coupled to the hand-held unit and having a pump having a dosing chamber.

A pet bed that provides an ideal resting place for pets is disclosed herein. The pet bed comprises a fabric shell and a bed filler contained within the fabric shell. The fabric shell defines a support region and a continuous sidewall emanating therefrom to surround an open center area. The fabric shell is made of organic hemp canvas and the bed filler is made of organic latex. The bed filler comprises a padding made of organic latex. A cushion is removably positioned in the center area of the fabric shell. At least one pocket is disposed on the sidewall of the fabric shell, and a healing crystal is removably inserted within the pocket. As a result, the pet bed spreads positive energy and provides comfort, healing, wellness, happiness and peace of mind to a pet and a pet owner.