Systems, devices and methods for modulation of sirtuins by neurostimulation. In particular, sirtuins may be modulated by stimulation of the vagus nerve. Further described herein generally are methods, systems and devices, for specifically modulating sirtuins, including sub-sets (types or localized regions) of sirtuins by vagus nerve stimulation (VNS).

A lead assembly includes an implantable lead. Electrodes are disposed along a distal end of the lead in an electrode array. Terminals are disposed along a proximal end of the lead in a proximal-most terminal array and a medial terminal array. A terminal extension electrically couples to the medial terminal array. A port is defined in a connector at a first end of the terminal extension. The port has a first end and an opposing second end and forms a continuous passageway therebetween. The port receives the medial terminal array. A contact array includes connector contacts that are disposed within the port and that couple electrically with a terminal array disposed along a second end of the terminal extension. The contact array couples electrically with terminals of the medial terminal array of the lead when the medial terminal array is received by the port.

An implantable processor arrangement is described for an active implantable medical device (AIMD) system implanted under the skin of a patient. An implantable communications coil arrangement is configured for transdermal transfer of an implant communications signal. An implantable processor is coupled to and controls the implantable communications coil arrangement so as to operate in two different communications modes. In a normal operation mode, the processor configures the communications coil arrangement for peridermal communication with an external communications coil placed on the skin of the patient immediately over the implantable communications coil arrangement. In a long range telemetry mode, the processor configures the communications coil arrangement for extradermal communication with an external telemetry coil located distant from the skin of the patient immediately over the implantable communications coil arrangement.

A conductive fluid reservoir can be used to dispense conductive fluid to increase electrical connectivity between an electrode of a defibrillator and a patient. The reservoir includes a container that holds the conductive fluid, one or more outlets on the container, and an inflatable pouch located at least partially within the container. The inflatable pouch is capable of being inflated from a deflated state to an inflated state. In the deflated state, a free end of the inflatable pouch covers the one or more outlets. In the inflated state, the free end of the inflatable pouch is removed from the one or more outlets such that the conductive fluid is allowed to flow out of the container via the one or more outlets. Inflating the inflatable pouch causes the conductive fluid to be dispensed from the reservoir.

Disclosed is a fibrous triboelectric generator. The fibrous triboelectric includes a first textile; a first electrode layer that is formed on a surface of the first textile; a friction layer that is formed on a surface of the first electrode layer and is able to be electrically charged by friction; and a second electrode layer that is able to undergo friction with the friction layer.

An electrical stimulation system includes an implantable control module configured and arranged for implantation in a body of a patient. The implantable control module includes a processor that generates and delivers electrical stimulation pulses or pulse bursts at a pathological frequency or with a temporal separation between pulses or pulse bursts individually selected based on a pre-determined distribution function based on a pre-selected pathological frequency.

In embodiments, a wearable cardiac defibrillation (WCD) system includes one or more flexible ECG electrodes. The WCD system may have a support structure that is dimensioned to be worn so as to press the electrodes towards the body of the patient. The electrodes may be made from appropriate material so as to flex in order to match a contour of the body of the patient. An advantage over the prior art is that the flexible electrode may make better electrical contact with the patient's skin, and therefore provide a better ECG signal for the WCD system to perform its diagnosis.

Embodiments of the present disclosure include medical apparatus, and related methods thereof. The apparatus may include a longitudinally extending lead, at least one electrode, an anchor component, and a control module. The lead may include a distal end and a proximal end. The at least one electrode may be coupled to the lead, wherein the at least one electrode may be disposed on the distal end of the lead. The anchor component may be disposed in the lead proximate of the at least one electrode. The anchor component may include solder. The control module may be operably coupled to the proximal end of the lead and may be configured to deliver energy to the at least one electrode.

A novel therapeutic biphasic or multiphasic pulse waveform and method are provided. The novel therapeutic biphasic or multiphasic pulse waveform may be used in a defibrillator, or in another medical device that delivers therapeutic electrical stimulation pulses to a patient.

Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods. A method for treating a patient in accordance with a particular embodiment includes selecting a neural modulation site to include a neural population of the patient's spinal cord, and selecting parameters of a neural modulation signal to at least reduce an autonomic system deficit in the patient.