A coil configuration and method for transcranial magnetic stimulation enabling stimulation of deep regions of the brain without excessively stimulating the cortex is provided. The coil configuration utilizes at least one coil to produce an off-plane magnetic field to enhance the magnetic field from a top TMS coil. In one configuration three coils, referred to as the Triple Halo Coil and oriented at +30°, 0°, and −30° relative to the plane of the TMS coil, are used. In another configuration a single variable position coil referred to as the Variable Halo Coil and positionable vertically and/or angularly is used.

A system for integrated electric field simulation and neuronavigation includes a neuronavigation system configured to track an electromagnetic coil used for neuromodulation of a brain of a subject and an electric field simulation neural network coupled to the neuronavigation system. The electric field simulation neural network is configured to generate a simulated electric field for a region of interest based at least on a coil position and orientation, a magnetic field profile of the electromagnetic coil, and multimodal neuroimaging data associated with the subject. The system further includes a display coupled to the electric field simulation neural network and configured to display the simulated electric field. The region of interest can be the brain of the subject and the electromagnetic coil can be a transcranial magnetic stimulation (TMS) coil.

The present disclosure provides, in part, methods of treatment for Alzheimer’s disease comprising applying repetitive transcranial magnetic stimulation (rTMS) therapy to a patient in need thereof. The present disclosure also provides devices that generate a low intensity pulsed magnetic field and variable frequencies.

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.

The present invention relates to a nanosatellite-substrate complex capable of regulating stem cell adhesion and differentiation, and a method for preparing the same. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation by applying a magnetic field to the nanosatellite-substrate complex.

The present invention concerns a system for treating cancer or tumors by thermotherapy, comprising an expandable implant device, an excitation catheter and an electric power source, wherein the implant device configured for circumferentially subtending a vessel upon expansion of the implant device in said vessel, the implant device comprising a set of cross-connected conductors forming a circumferential structure with openings in between the conductors, said openings having a minimal opening distance when the implant device is expanded of at least 2 mm, wherein the excitation catheter comprises a longitudinal shaft with a distal end, a proximal end, and a longitudinal body in between, whereby the catheter comprises a longitudinal axis along the longitudinal shaft, and whereby the catheter further comprises an emitter coil at or near the distal end, and whereby the longitudinal body of the catheter further comprises a wiring lumen comprising electrical wiring extending from the distal end to the proximal end, and whereby the electrical wiring is connected at or near the distal end with the emitter coil, and wherein the electric power source is connectable, and preferably connected, to the wiring via the proximal end of the catheter shaft for the generation of a time-varying magnetic field with the emitter coil.

Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.

The present disclosure provides a combined Pulsed Electromagnetic Field (PEMF) therapy and Photobiomodulation (PBM) therapeutic device in the form of a flexible wearable that can be secured to a user's body part to apply targeted radiation to a desired area. The frequencies and pulse patterns of both types of radiation are controlled by a single controller of the device which can switch between a number of pre-set sequences and patterns. The device is wirelessly enabled to allow control via an external user device.

A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform the method.

A neurostimulation system is disclosed for providing treatment to a patient during a therapy session. The neurostimulation system includes a neurostimulator for transmitting magnetic or electrical signals based upon a treatment program. A programmer is connected to the neurostimulator to set a treatment session parameter value to calculate a therapy compliance value. A compliance module is connected to the neurostimulator and the programmer to calculate and store a therapy compliance value. A control module is connected to the compliance module, the programmer and the neurostimulator and determines whether the therapy compliance value is within a range of the treatment program. The neurostimulator transmits electrical or magnetic signals to the patient in a treatment session only if the therapy compliance value meets a compliance criteria.