A device for cooling the skin tissue of a patient during a procedure using energy includes a mat-like structure, the mat-like structure having a bottom wall, a top wall and upstanding walls connecting the top wall and the bottom wall, the walls defining an enclosed volume; it also includes one or more electrodes positioned to protrude from the bottom wall and extend through the volume for connection to a source of energy; further, the volume defines a space for holding a cooling substance for cooling the one or more electrodes and the skin tissue during an energy-based procedure.

A device for cooling the skin tissue of a patient during a procedure using energy includes a mat-like structure, the mat-like structure having a bottom wall, a top wall and upstanding walls connecting the top wall and the bottom wall, the walls defining an enclosed volume; it also includes one or more electrodes positioned to protrude from the bottom wall and extend through the volume for connection to a source of energy; further, the volume defines a space for holding a cooling substance for cooling the one or more electrodes and the skin tissue during an energy-based procedure.

Numerous aspects of communication devices, methods, and systems are described in this application. One aspect is a system comprising a body having a skin facing surface and an opposing surface and an energy generator operably coupled to the body and comprising a plurality of generator elements operable to output a plurality of different energy types in a signal direction toward skin. Each generator element of the plurality of generator elements may be independently operable to output one energy type of the plurality of different energy types in the signal direction. When the skin facing surface of the body is positioned relative to the skin, the energy generator may affect tissues associated with or adjacent to the skin by causing one or more generator elements of the plurality of generator elements to output an energy signal in the signal direction with one or more different energy types.

The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.

The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.

A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors.

A skin treatment device for home use is provided herein. The device has enhanced safety features and improved operation efficiency. RF energy is delivered under strict control to a relatively small and well localized volume of the skin, avoiding excessive heating of the skin surface. Surface heating is monitored both by direct temperature measurement and by movement monitoring of the device to ensure proper use and prevent skin overheating and the pain associated therewith.

A skin treatment device for home use is provided herein. The device has enhanced safety features and improved operation efficiency. RF energy is delivered under strict control to a relatively small and well localized volume of the skin, avoiding excessive heating of the skin surface. Surface heating is monitored both by direct temperature measurement and by movement monitoring of the device to ensure proper use and prevent skin overheating and the pain associated therewith.

By producing the proper wave interference using superimposed angularly separate waves that overlap with the proper time-phase relationship (called “Time-Correlated Standing-wave Interference”), wave energy is amplified (by “Coherent Intensity Amplification”) and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be “teleported” to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to different locations.

A pneumatic compression assembly that includes a sleeve having an outer layer and an inner layer that defines a sleeve interior configured to receive a body part of a user, and at least a first vibration assembly configured to provide vibration to the body part of the user. A plurality of inflatable compartments are arranged longitudinally along the sleeve between the inner layer and the outer layer. The first vibration assembly includes a plurality of vibration motors positioned between the inner layer and the outer layer of the sleeve.