Provided are methods for improving exercise performance and endurance of a mammal, comprising administering to the mammal in need thereof a composition comprising dihydroberberine (DHB), or an analog or derivative thereof, and a physiologically acceptable carrier. DHB in the composition can serve as an antioxidant to defend red blood cells against oxidative stress damage, by scavenging reactive oxygen species generated during to increase the deformability and the survival of red blood cells.

Provided are methods for improving exercise performance and endurance of a mammal, comprising administering to the mammal in need thereof a composition comprising dihydroberberine (DHB), or an analog or derivative thereof, and a physiologically acceptable carrier. DHB in the composition can serve as an antioxidant to defend red blood cells against oxidative stress damage, by scavenging reactive oxygen species generated during to increase the deformability and the survival of red blood cells.

The present invention relates to a composition for enhancing exercise capacity and recovery from fatigue containing fermented and aged noni, coconut sugar or muscovado sugar as an active ingredient, and more specifically, to a composition enhancing exercise capacity and recovery from fatigue, which has the effects of enhancing exercise capacity and inhibiting the accumulation of fatigue substances in blood by increasing glycogen storage in tissue and liver function. The present invention provides a food composition for exercise capacity enhancement and anti-fatigue, which is useful in the food industry. The composition of the present invention enables recovery from fatigue or enhancement of athletic ability to be achieved quickly by promoting the reduction of fatigue substances, and may provide sports drink products, functional food products and pharmaceutical composition products that are effective in enhancing recovery from fatigue and exercise capacity.

The present invention relates to a composition for enhancing exercise capacity and recovery from fatigue containing fermented and aged noni, coconut sugar or muscovado sugar as an active ingredient, and more specifically, to a composition enhancing exercise capacity and recovery from fatigue, which has the effects of enhancing exercise capacity and inhibiting the accumulation of fatigue substances in blood by increasing glycogen storage in tissue and liver function. The present invention provides a food composition for exercise capacity enhancement and anti-fatigue, which is useful in the food industry. The composition of the present invention enables recovery from fatigue or enhancement of athletic ability to be achieved quickly by promoting the reduction of fatigue substances, and may provide sports drink products, functional food products and pharmaceutical composition products that are effective in enhancing recovery from fatigue and exercise capacity.

Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.

The present application is concerned with methods for increasing the bioavailability and/or activity of agents and in particular allows selective targeting of an agent to, or via, the liver or allows the liver to be bypassed. By selecting which of saturated fatty acids (SFA), short chain fatty acids (SCFA), medium chain fatty acids (MCFA), polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFAs) and long chain fatty acids (LCFA) are present in a composition and which predominates it is possible to substantially boost bioavailability and also to selectively target whether an agent is delivered to, or via, the liver or alternatively bypasses the liver. The approach is a versatile platform technology which may be applied to agents in general helping achieve better and more efficient delivery. In one preferred embodiment particular carotenoids are employed to further influence whether delivery is to, or via, the liver, or bypasses the liver.