Some embodiments of the methods and compositions provided herein include methods of reducing surgery-induced metastases in a subject with cancer following surgery to remove at least one solid tumor, comprising an NADPH oxidase inhibitor to said subject.

Some embodiments of the methods and compositions provided herein include methods of reducing surgery-induced metastases in a subject with cancer following surgery to remove at least one solid tumor, comprising an NADPH oxidase inhibitor to said subject.

The invention provides carbazole derivatives for the treatment of fibrotic diseases (pathological collagen deposition) in tissues and organs, and related symptoms, and conditions thereof.

The invention provides carbazole derivatives for the treatment of fibrotic diseases (pathological collagen deposition) in tissues and organs, and related symptoms, and conditions thereof.

Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation.

Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation.

A method for bone healing or treatment of bone fracture in a subject includes optionally pre-drilling a hole or creating a cavity in a body tissue, implanting a device onto or into the body tissue, or at least partially inserting a device into the cavity or hole, administering a composition into the device and/or near the device. The composition includes a first finely divided particulate material, and can optionally include at least a second material. The first material is not bioresorbable or is very slowly bioresorbable and the second material or materials are bioresorbable at a higher rate than the first material. The method can optionally include fully inserting the device into the hole or cavity, and can optionally include administering a pharmaceutical composition to the subject.

A method for bone healing or treatment of bone fracture in a subject includes optionally pre-drilling a hole or creating a cavity in a body tissue, implanting a device onto or into the body tissue, or at least partially inserting a device into the cavity or hole, administering a composition into the device and/or near the device. The composition includes a first finely divided particulate material, and can optionally include at least a second material. The first material is not bioresorbable or is very slowly bioresorbable and the second material or materials are bioresorbable at a higher rate than the first material. The method can optionally include fully inserting the device into the hole or cavity, and can optionally include administering a pharmaceutical composition to the subject.

The present invention relates to the treatment of tissue adhesions, e.g. tissue adhesions that occur after surgical interventions. More specifically, the invention refers to an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions. The invention also relates to a pharmaceutical composition that comprises an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions.

The present invention relates to the treatment of tissue adhesions, e.g. tissue adhesions that occur after surgical interventions. More specifically, the invention refers to an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions. The invention also relates to a pharmaceutical composition that comprises an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions.