This invention relates to a cosmetic composition comprising: (A) a film forming composition that can produce a tack free surface comprising: (I) a hydrosilylation reaction product of: (a) a silicone resin having the formula: (R.sup.1R.sup.2.sub.2SiO.sub.1/2)w(R.sup.1R.sup.2SiO.sub.2/2).sub.x(R.sup.2SiO.sub.3/2).sub.y(SiO.sub.4/2).sub.z wherein R.sup.2 is a C.sub.1 to C.sub.10 hydrocarbon group free of aliphatic unsaturation, R.sup.1 is R.sup.2 or an alkenyl group, w is from 0.3 to 0.6, x is from 0.0 to 0.2, y is 0, z is from 0.4 to 0.7, w+x+y+z=1.0, and w+z is from 0.85 to 1.0, with the proviso that the silicone resin (a) has at least two silicon-bonded alkenyl groups per number average molecule; (b) a polyether compound having the formula: R.sup.3O(C.sub.2H.sub.4O).sub.c(C.sub.3H.sub.6O).sub.dR.sup.3 wherein R.sup.3 is a monovalent unsaturated aliphatic hydrocarbon group containing 2 to 12 carbon atoms, c is from 0 to 50, d is from 0 to 50, and the value of c+d is greater than zero; (c) an SiH functional organopolysiloxane having the general formula: H.sub.cR.sub.3-cSiO(R.sub.2SiO).sub.a(RHSiO).sub.bSiR.sub.3-cH.sub.c wherein c is 0 or 1, R can be identical or different and is a monovalent, optionally substituted hydrocarbon group with 1 to 18 carbon atoms per molecule, a and b are integers, with the proviso that the sum of a+b is 0 to 300, and wherein the organopolysiloxane contains SiH in amounts from 0.01 to 0.4 wt %; (d) a hydrosilylation catalyst; and (e) carrier solvent; and (II) a silicone resin having the formula: (R.sup.4.sub.3SiO.sub.1/2).sub.u(SiO.sub.4/2).sub.v wherein R.sup.4 is a C.sub.1 to C.sub.10 to do hydrocarbon group free of aliphatic unsaturation, u is from 0.3 to 0.6, v is from 0.4 to 0.7, and the value of u+v is 1.0; and (B) at least one cosmetic ingredient.

A water-soluble silicon-containing granulate comprising a silicon compound of the formula Y.sub.xSi(OH).sub.4-x or an oligomer thereof, wherein Y is optionally substituted (C.sub.1-C.sub.4)alkyl, (C.sub.2-C.sub.5)-alkenyl, (C.sub.1-C.sub.4)-alkoxy, amino, and wherein x is 0-2, and a cold-water soluble starch material.

Multi-component pharmaceutical compositions perform various functions and confer various benefits, but often with reduced benefits resulting from interference and cancellation effects between components. To avoid this problem multi-component pharmaceutical compositions can include three separate compositions, each differing by at least one component, or in which all components differ. Doses from each composition are taken over a given period of time, such as a day. One dose from a first composition is taken in the morning, a dose from a second composition is taken at mid-day, and a dose from a third composition is taken at night, for example. Methods of preventing, treating, and mitigating various diseases and disorders, including Alzheimer's disease and related disorders, autism spectrum disorders, cancer, and thrombosis also appear.

Multi-component pharmaceutical compositions perform various functions and confer various benefits, but often with reduced benefits resulting from interference and cancellation effects between components. To avoid this problem multi-component pharmaceutical compositions can include three separate compositions, each differing by at least one component, or in which all components differ. Doses from each composition are taken over a given period of time, such as a day. One dose from a first composition is taken in the morning, a dose from a second composition is taken at mid-day, and a dose from a third composition is taken at night, for example. Methods of preventing, treating, and mitigating various diseases and disorders, including Alzheimer's disease and related disorders, autism spectrum disorders, cancer, and thrombosis also appear.

The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and/or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, Tinea versicolor, Pityriasis versicolor, Tinea circinata, Tinea pedis, Tinea unguium, Tinea manus, Tinea cruris, Tinea corporis, Tinea faciei, Tinea capitis, and/or Tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

A complex formed by a zinc oxide molecule and a molecule comprising an acidic hydrogen is disclosed. The oxygen atom of the zinc oxide molecule is covalently bound to the acidic hydrogen.

Provided herein are non-naturally occurring polypeptides comprising a sequence of a fragment of a collagen and recombinant cells containing heterologous nucleic acid sequences encoding the non-naturally occurring polypeptides. Further provided herein are animal-free methods of generating and purifying such non-naturally occurring polypeptides using microorganisms, preferably from bacterial cells.

A complex formed by a zinc oxide molecule and a molecule comprising an acidic hydrogen is disclosed. The oxygen atom of the zinc oxide molecule is covalently bound to the acidic hydrogen.

Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.

Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.