The invention relates to aqueous formulations for topical nail application. The invention also relates to compositions for use in the treatment of a fungal nail infection, the composition being applied over a defined period.

Provided herein are non-naturally occurring polypeptides comprising a sequence of a fragment of a collagen and recombinant cells containing heterologous nucleic acid sequences encoding the non-naturally occurring polypeptides. Further provided herein are animal-free methods of generating and purifying such non-naturally occurring polypeptides using microorganisms, preferably from bacterial cells.

The present disclosures are directed to compositions comprising a polymer having linear or branched silicone substituted by at least one alkylcarboxy group and cross-linked with an alkyl functional cross-linker, which has the benefits of compatibility and structuring of personal care components and the resultant personal care applications.

Provided herein are non-naturally occurring polypeptides comprising a sequence of a fragment of a collagen and recombinant cells containing heterologous nucleic acid sequences encoding the non-naturally occurring polypeptides. Further provided herein are animal-free methods of generating and purifying such non-naturally occurring polypeptides using microorganisms, preferably from bacterial cells.

The invention relates to a false nail comprising at least: one front layer (12) forming the body of the false nail (1), and a rear layer (11) of an adhesive material for attaching the body of the false nail to a natural nail. The rear layer (11) is formed by a fast-drying polymer adhesive with desiccating capacity, and the front layer (12) is made of a composite material and comprises at least a first layer (12a) of micro-hybrid composite with low contraction capacity in contact with the polymer adhesive. The invention also relates to a method for shaping the false nail on a natural nail and the use of composite material to shape same.

The invention relates to a false nail comprising at least: one front layer (12) forming the body of the false nail (1), and a rear layer (11) of an adhesive material for attaching the body of the false nail to a natural nail. The rear layer (11) is formed by a fast-drying polymer adhesive with desiccating capacity, and the front layer (12) is made of a composite material and comprises at least a first layer (12a) of micro-hybrid composite with low contraction capacity in contact with the polymer adhesive. The invention also relates to a method for shaping the false nail on a natural nail and the use of composite material to shape same.

The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and/or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, tinea versicolor, pityriasis versicolor, tinea circinata, tinea pedis, tinea unguium, tinea manus, tinea cruris, tinea corporis, tinea faciei, tinea capitis, and/or tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

A complex formed by a zinc oxide molecule and a molecule comprising an acidic hydrogen is disclosed. The oxygen atom of the zinc oxide molecule is covalently bound to the acidic hydrogen.

A cosmetic including an acryl silicone copolymer having a (meth)acrylic chain in the main chain and a structure containing at least a silicone macromonomer shown by the following general formula (1) as the monomer unit (the acryl silicone copolymer has a refractive index of 1.47 or more). A novel glossy cosmetic that is free from tautness or stiffness unlike previous silicone resin coatings, excellent in feeling of use, adherence, and flexibility, as well as good in effect for preventing color transfer. ##STR00001##

Compositions comprising one or more of the following extracts: an Euterpe oleracea extract comprising cyanidin 3-glycoside and/or cyanidin 3-rutinoside, an Olea europaea extract comprising oleuropein, a Coffea arabica extract, and/or a Tabebuia impetiginosa extract. The compositions further comprise a micronutrient comprising zinc and vitamin D3. Dietary supplements and hair/body care products comprising the compositions. The compositions are useful for non-medicinal treatment of hair loss and/or nourishment and rejuvenation of hair, skin and nails.