The present invention refers to a method for the synthesis of a biodegradable calcium release material that shows controlled ion release properties for tissue engineering, biomaterials containing the calcium particles as well as the calcium particles obtainable therefrom. By varying the treatment temperature of the described method, the calcium material shows different calcium release profiles. Contrary to a specific chemical composition such as CaCO.sub.3 which is associated to a specific calcium release profile, the present invention allows a manifold of compositions, with a manifold of calcium release profiles, all starting from a single specific chemical composition calcium precursor. Therefore, the invention also relates to the use of the controllable release, calcium material in tissue regeneration such as wound healing processes.

The present invention refers to a method for the synthesis of a biodegradable calcium release material that shows controlled ion release properties for tissue engineering, biomaterials containing the calcium particles as well as the calcium particles obtainable therefrom. By varying the treatment temperature of the described method, the calcium material shows different calcium release profiles. Contrary to a specific chemical composition such as CaCO.sub.3 which is associated to a specific calcium release profile, the present invention allows a manifold of compositions, with a manifold of calcium release profiles, all starting from a single specific chemical composition calcium precursor. Therefore, the invention also relates to the use of the controllable release, calcium material in tissue regeneration such as wound healing processes.

It is an object of the present invention to provide a new agent for the treatment of alopecia, the agent being not only effective and safe for, in particular, alopecia areata, androgenetic alopecia in a male, androgenetic alopecia in a female, female pattern alopecia, postpartum alopecia, seborrheic alopecia, alopecia pityroides, senile alopecia, cancer chemotherapy drug-induced alopecia, and alopecia due to radiation exposure, but also effective for a target having resistance to treatment with minoxidil or finasteride, there being no side effects such as an itching sensation, irritation, or feminization, and no contraindications, the agent suppressing dandruff or having a therapeutic effect for white hair, and the therapeutic effect for alopecia being maintained for a long period even when use of the agent is stopped. The solution means of the present invention is an agent for the treatment of alopecia containing as an active ingredient a C-type natriuretic peptide (CNP), a B-type natriuretic peptide (BNP), a derivative of these NPs, a chimeric peptide of these NPs, or a derivative of a chimeric peptide of these NPs.

It is an object of the present invention to provide a new agent for the treatment of alopecia, the agent being not only effective and safe for, in particular, alopecia areata, androgenetic alopecia in a male, androgenetic alopecia in a female, female pattern alopecia, postpartum alopecia, seborrheic alopecia, alopecia pityroides, senile alopecia, cancer chemotherapy drug-induced alopecia, and alopecia due to radiation exposure, but also effective for a target having resistance to treatment with minoxidil or finasteride, there being no side effects such as an itching sensation, irritation, or feminization, and no contraindications, the agent suppressing dandruff or having a therapeutic effect for white hair, and the therapeutic effect for alopecia being maintained for a long period even when use of the agent is stopped. The solution means of the present invention is an agent for the treatment of alopecia containing as an active ingredient a C-type natriuretic peptide (CNP), a B-type natriuretic peptide (BNP), a derivative of these NPs, a chimeric peptide of these NPs, or a derivative of a chimeric peptide of these NPs.

Methods and compositions for stimulating hair growth are disclosed. Compositions for stimulating hair growth include two or more of hyaluronic acid, osteopontin, and another CD44 binding ligand. Methods for stimulating hair growth include administering such composition into the skin of a patient.

Methods and compositions for stimulating hair growth are disclosed. Compositions for stimulating hair growth include two or more of hyaluronic acid, osteopontin, and another CD44 binding ligand. Methods for stimulating hair growth include administering such composition into the skin of a patient.

The present invention relates to the preparation of 9-deoxo-36,37-dihydro-prolylFK506, 9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506, 9-deoxo-prolylFK520 or 9-deoxo-31-O-demethyl-prolylFK520, which are novel compounds that can be utilized as the main ingredient of a composition for promoting hair growth, and the use thereof in promoting hair growth.

The present invention relates to the preparation of 9-deoxo-36,37-dihydro-prolylFK506, 9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506, 9-deoxo-prolylFK520 or 9-deoxo-31-O-demethyl-prolylFK520, which are novel compounds that can be utilized as the main ingredient of a composition for promoting hair growth, and the use thereof in promoting hair growth.

An oriental shampoo composition that can help maintain the health of the scalp and hair and help alleviate hair loss is provided. The shampoo composition includes, among others, 47.89% by weight of purified water; 10.00% by weight of a herbal mixed solution containing purified water, Rehmannia chinensis root extract, butylene glycol, Mentha arvensis extract, 1,2-hexanediol, Acorus gramineus root extract, Biota orientalis leaf extract, Chrysanthemum zawadskii extract, Panax ginseng root extract, Glycyrrhiza galbra (licorice) root extract, Lycinum chinense fruit extract, Morus alba bark extract, Xanthium strumarium fruit extract, and ethyl hexyl glycerin; 10.00% by weight of a mixed solution containing sodium lauryl sulfate, purified water, disodium phosphate and sodium carbonate; 10.00% by weight of a mixed solution containing purified water, TEA-lauryl sulfate and sodium benzoate; and 8.0% by weight of a mixed solution containing purified water, cocamidopropyl betaine and sodium chloride.

An oriental shampoo composition that can help maintain the health of the scalp and hair and help alleviate hair loss is provided. The shampoo composition includes, among others, 47.89% by weight of purified water; 10.00% by weight of a herbal mixed solution containing purified water, Rehmannia chinensis root extract, butylene glycol, Mentha arvensis extract, 1,2-hexanediol, Acorus gramineus root extract, Biota orientalis leaf extract, Chrysanthemum zawadskii extract, Panax ginseng root extract, Glycyrrhiza galbra (licorice) root extract, Lycinum chinense fruit extract, Morus alba bark extract, Xanthium strumarium fruit extract, and ethyl hexyl glycerin; 10.00% by weight of a mixed solution containing sodium lauryl sulfate, purified water, disodium phosphate and sodium carbonate; 10.00% by weight of a mixed solution containing purified water, TEA-lauryl sulfate and sodium benzoate; and 8.0% by weight of a mixed solution containing purified water, cocamidopropyl betaine and sodium chloride.