The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present invention relates to a method for treatment of a slurry comprising a liquid and particles suspended in the liquid. The method comprising the steps of providing a slurry to be treated; subjecting the slurry to a separating stage in which the particles of the slurry are divided into at least two subsets, a first subset being generally less difficult to dewater than a second subset; feeding a pressure filter with a flow of the first and second subsets, wherein in a first feeding step, a major part of the flow is defined by the first subset and in a subsequent second feeding step, a major part of the flow is defined by the second subset.

Z-filter media pack arrangements and methods for providing them are described. The preferred arrangements have a cured-in-place jacket around an outside of a coiled z-filter media combination. The preferred cured-in-place jacket is a mold-in-place overmold which includes, integral therein, a housing seal arrangement. Preferably a cured-in-place center core is used, most preferably one that has opposite concave ends with seal arrangements configured to seal a lead end portion of the coiled z-filter media combination.

A modular, compact, mobile, dewatering and liquid-liquid separation and filtration system. The system processes incoming influents of slurries, solids and liquids at a high speed of operation and in large volumes. System is capable of being modularly scaled, allowing for a continuous steady state operation accommodating any slurry flow rate in a synchronous dynamic equilibrium process. Components and modules integrated into the system include a dynamic filtration clarifier 101 (DFC), a nested-filter dewatering cell 115 (NDC) and/or a compression filter press 125 (CFP). The DFC performs the primary dewatering phase of separating the primary water from the solids creating sludge. The NDC further breaks apart the solids of the sludge, removing interstitial water in a secondary dewatering phase, further lowering the moisture content of the sludge, while the CFP removes the tertiary water from the remaining solid particles by pressing the particles into a solid cake.

A modular, compact, mobile, dewatering and liquid-liquid separation and filtration system. The system processes incoming influents of slurries, solids and liquids at a high speed of operation and in large volumes. System is capable of being modularly scaled, allowing for a continuous steady state operation accommodating any slurry flow rate in a synchronous dynamic equilibrium process. Components and modules integrated into the system include a dynamic filtration clarifier 101 (DFC), a nested-filter dewatering cell 115 (NDC) and/or a compression filter press 125 (CFP). The DFC performs the primary dewatering phase of separating the primary water from the solids creating sludge. The NDC further breaks apart the solids of the sludge, removing interstitial water in a secondary dewatering phase, further lowering the moisture content of the sludge, while the CFP removes the tertiary water from the remaining solid particles by pressing the particles into a solid cake.

A cleaner includes: a main body that receives a suction motor; and a filter unit that is detachably coupled to the main body to filter air discharged from the suction motor and includes a ring-shaped filter and a filter frame that receives the ring-shaped filter, wherein the filter frame includes: an inner frame; an outer frame that defines a filter space for receiving the filter in cooperation with the inner frame; and a ring-shaped filter cover that connects the outer frame and the inner frame to each other and has one or more air openings.

A filtration module (1) has a filter unit (2) with at least one filter element (6) arranged between first and second plates (4, 5). The filter element (6) has at least one layer of filter material (9, 10) sealed off at a periphery by an edge seal (12). The plates (4, 5) are pressed against each other by a resilient bracketing profile (3) that engages around the plates (4, 5) at their opposite side surfaces (21, 22, 23, 24). The bracketing profile (3) has a base (13) that curves inward transversely to the longitudinal direction (14) of the plates (4, 5) and that is delimited by lateral brackets (16, 17) that are bent inward at their free ends (18, 19) to engage laterally around a surface (20) of the filter element (6) facing away from the base (13). A method also is provided for producing a filtration module.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A horizontal pressure filter including a washing liquid recovery channel for receiving unused washing liquid from the washing liquid inlet channel and conducting said unused washing liquid to a washing liquid recovery outlet. A flow controller arranged to selectively open and close a flow connection between the washing liquid inlet channel and the washing liquid recovery channel, and respectively, between a compressed gas inlet and the washing liquid inlet channel, such that a gas flow from the compressed gas inlet to the washing liquid recovery channel via the washing liquid inlet channel may be induced, so as to flush unused washing liquid remaining in the washing liquid inlet channel to the washing liquid recovery outlet.