The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A filter press (100) is described comprising: a plurality of filtration chambers (155) each of which is delimited by two mutually facing filtering septa (140, 145) interposed between a pair of containment plates (105), a movement apparatus adapted to move each pair of containment plates (105) between a closed configuration and an open configuration, an inlet hydraulic circuit of the liquid to be filtered, an outlet hydraulic circuit of the filtered liquid, and a washing robot (400) adapted to wash the filtering septa (140, 145) that delimit each filtration chamber (155), wherein said washing robot (400) comprises: a trolley (405) adapted to move along a longitudinal direction (A) with respect to the containment plates (105), a bar (445) installed on the trolley (405) and movable relative thereto in a transverse direction with respect to the longitudinal direction (A), and a plurality of nozzles (450) installed on said bar (445) to dispense jets of a washing liquid toward said filtering septa (140, 145), the filter press further comprising: a plurality of identification codes, each of which is fixed to at least one respective filtering septum (140, 145), a device for detecting said identification codes installed on the trolley (405) of the washing robot (400), at least one image acquisition device (600) installed on the bar (445) of the washing robot (400) to acquire images of said filtering septa (140, 145), and an electronic processing unit connected to the identification code detection device and to the image acquisition device (600).

Provided is a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media held in a housing for holding the two or more filter cartridges in about the same orientation, and an attachment clamp connected to the housing. Also provided is a housing for holding two or more filter cartridges in about the same orientation and a method of using the filter apparatus and housing.

A filter attachment and detachment apparatus removably attaching a filter container containing a filter, as a part of a filtration apparatus that filters fluid with the filter, includes a first mounting protrusion at one end of the filter container to protrude from the filter container, the first mounting protrusion including a flow path in fluid communication with the filter inside the filter container, a rotation element to which a first flow path for the fluid is connected, the rotation element including an opening groove configured to receive the first mounting protrusion, and a first mounting protrusion holding part configured to rotatably hold the rotation element. The first mounting protrusion holding part includes an inner periphery surface and a notch communicating with an outer side of the inner periphery surface, where in a state where the first mounting protrusion is inserted into the opening groove through the notch, by rotating the rotation element, the first mounting protrusion is bound between the inner periphery surface of the first mounting protrusion holding part and the rotation element.

Filter media (100) for dewatering slurry is disclosed. The filter media (100) may comprise a filtering body (105) comprising non-occluded porous material (105a) and occluded porous material (105b). At least one upper tab (101) comprising at least one upper locking element (102) and at least one lower tab (104) comprising at least one lower locking element (103) may be provided to the filter media (100) as means for attaching the filter media (100) to a filter plate (300). The filter plate (300) may comprise at least one upper locking element (302) provided to an upper end surface (301) of the filter plate (300) and at least one lower locking element (303) provided to a lower end surface (304) of the filter plate (300); wherein the at least one upper tab (101) of the filter media (100) is configured to communicate with the at least one upper locking element (302) of the filter plate (300) and wherein the at least one lower tab (104) of the filter media (100) is configured to communicate with the at least one lower locking element (303) at the lower end surface (304) of the filter plate (300). A method of manufacturing the filter media is also described.

A filling shoe including a circular slurry opening extending between a filter plate side and a filter chamber side. A flange surrounds the slurry opening, and has an annular groove surrounding it and being arranged for receiving a filter medium. An outer edge of the body has a bevel towards the filter plate side on at least a part of the filling shoe. An outer edge of the flange is also provided with a bevel. Particularly, the filling shoe is formed as a single uniform piece of elastomer. A pin hole is provided so as to extend through the flange a position corresponding to the annular groove. A filling shoe arrangement, a filter medium assembly and a method for providing a filter medium with a filling shoe are also disclosed.

A recess plate designed for use in a filter device for filtering a suspension includes a stationary head piece and a movable end piece, and a pack including copies of the recess plate, having a filter chamber inside the pack, adjoining the recess plate, having a first pipe for filling the suspension into the filter chamber, having a filter cloth for collecting a solid content out of the suspension, and having a second pipe for discharging a liquid fraction of the suspension out of the filter chamber as a filtrate, wherein the filter device may be closed before filtering by forcing the end piece in direction of the head piece, and opened after filtering by releasing the end piece, and moving the end piece away from the head piece for removing the filter cake from the filter cloth.

A water purification system utilizes an ionomer membrane and mild vacuum to draw water from source water through the membrane. A water source may be salt water or a contaminated water source. The water drawn through the membrane passes across the condenser chamber to a condenser surface where it is condensed into purified water. The condenser surface may be metal or any other suitable surface and may be flat or pleated. In addition, the condenser surface may be maintained at a lower temperature than the water on the water source side of the membrane. The ionomer membrane may be configured in a cartridge, a pleated or flat plate configuration. A latent heat loop may be configured to carry the latent heat of vaporization from the condenser back to the water source side of the ionomer membrane. The source water may be heated by a solar water heater.

A water purification system utilizes an ionomer membrane and mild vacuum to draw water from source water through the membrane. A water source may be salt water or a contaminated water source. The water drawn through the membrane passes across the condenser chamber to a condenser surface where it is condensed into purified water. The condenser surface may be metal or any other suitable surface and may be flat or pleated. In addition, the condenser surface may be maintained at a lower temperature than the water on the water source side of the membrane. The ionomer membrane may be configured in a cartridge, a pleated or flat plate configuration. A latent heat loop may be configured to carry the latent heat of vaporization from the condenser back to the water source side of the ionomer membrane. The source water may be heated by a solar water heater.