A microfluidic device includes first and second substrate structures. The first substrate structure has a first substrate surface configured to receive one or more droplets. A plurality of electrodes configured to apply an electric field to the droplets. The second substrate structure has a second substrate surface facing the first substrate surface and spaced apart from the first substrate surface to form a fluid channel. The microfluidic device has a first heating element adjacent to the first substrate structure and disposed on an opposite side of the first substrate surface, and a second heating element adjacent to the second substrate structure and disposed on an opposite side of the second substrate surface. The microfluidic device further includes one or more temperature sensors disposed adjacent to the fluid channel between the first substrate structure and the second substrate structure.

Provided are an active droplet generating apparatus capable of controlling a droplet size, a method of controlling a droplet size using the same, and a self-diagnosis apparatus for diagnosing generation of a droplet, the active droplet generating apparatus including: a disposable microchannel upper plate; a multifunctional lower plate separated from the disposable microchannel upper plate and configured to be permanently used separately from the disposable microchannel upper plate; a functional polymeric film provided on a lower surface of the upper plate; a negative pressure forming means; and a flow velocity control device configured to adjust the droplet size to a desired size by receiving, by feedback, the voltage value measured by the droplet measuring electrode and controlling flow velocities of the oil and the sample, thereby controlling the droplet size in a feedback control manner by quickly and accurately measuring the droplet size using a capacitance impedance technique.

A stirring device for stirring a biphasic fluid has a stirring shaft that can be mounted with a mounting end into a stirring drive. The stirring device also has a first paddle that is arranged in a rotationally fixed manner at or near a stirring end of the stirring shaft that is opposite to the mounting end, and further has a second paddle that is arranged in a rotationally fixed manner at the stirring shaft in between the mounting end and the first paddle. The second paddle is mounted with respect to the stirring shaft in such a manner that it can be displaced in an axial direction along the stirring shaft, which allows for a change of an axial distance between the second paddle and the mounting end of the stirring shaft.

Disclosed is a genetic diagnosis chip. The genetic diagnosis chip includes one or more unit processing parts, wherein the unit processing part includes a pretreatment unit that loads a sample and performs a pretreatment process on a target material in the loaded sample, and a distribution unit which is located radially outward from the pretreatment unit and in which the target material pretreated through the pretreatment unit is distributed and detection of the distributed target material is performed, the pretreatment unit includes a sample loading unit that loads the sample, and a capture channel which captures the target material from the loaded sample, and the sample loading unit is formed on the capture channel.

Concentrate filling system includes a solid loader operable to dispense particles through a dispensing end. The system includes a conveyer operable to receive the dispensed particles at a proximal end and further dispense particles at a distal end. The system includes load cell operable to receive a container that receives the dispensed particles. The system includes an injection pump to dispense fluids into the container. The system includes controller operable to receive data from the load cell indicative of a weight of the particles and/or fluid and send a control signal to the conveyor to adjust the dispensing of the particles and send a control signal to the injection pump. Upon receiving indicative of a predetermined weight of the container, fluid, and particles, the controller is operable to send a control signal to the conveyor and the injection pump to stop dispensing of particles and fluid.

A wearable sensor for monitoring an external bodily fluid includes a sensor thread, a wick, a substrate, and a communication interface all of which are disposed on a substrate. The wick wicks the external bodily fluid to a functionalized region of the thread. The communication interface transmits, to an external device, data indicative of what the sensor thread has measured in said external bodily fluid. The external device can then carry out real-time analysis or storage.

An apparatus and process or mixing granules and/or powders and/or liquids in rubber production plants, including: a mixer/extruder device for the production of a basic heterogeneous mixture; a plurality of distribution lines associated with said mixer/extruder device to supply the device itself with respective powdered and/or granulated and/or liquid products; the mixer/extruder device mixing the powdered and/or granulated and/or liquid products to obtain said heterogeneous mixture; at least one distribution line of a powdered product includes a pre-mixer arranged upstream of said mixer/extruder device to pre-mix said powdered product with at least one liquid product, preferably oil.

An insert for a liquid-holding container may include a body comprising a wall, an open top end and a bottom end, and a generally tubular lumen extending from the open top end to the open bottom end. The insert may include a plurality of first openings formed in the wall, the first openings being situated between the top and bottom ends, wherein each of the plurality of first openings defines an area, and wherein the plurality of first openings have substantially the same dimensions. The insert may include one or more second openings formed in the wall, the one or more second openings being situated between the top and bottom ends, wherein each of the one or more second openings defines an area that is greater than the area defined by any of the first openings, wherein the one or more second openings have substantially the same dimensions.

An insert for a liquid-holding container includes a body comprising a wall, open first and second ends, and a lumen extending from the open first end to the open second end. A plurality of first openings are formed in the wall, each of the first openings defining an area, and one or more second openings are formed in the wall, each of the one or more second openings defining an area that is greater than the area defined by any of the first openings. The first openings are arranged in a first row of at least three first openings in axial alignment and a second row of at least three first openings in axial alignment. At least one of the one or more second openings is situated closer to the first end than any of the first openings, and each of the first and second openings is sized to permit the passage of a liquid.

Microfluidic devices, kits systems and methods are provided for high throughput phenotypic separation of magnetically labelled cell samples. The devices and methods can be used for example to sort cells based on level of target marker and to sort screen cells, such as CRISPR screen cells and other screens with a large number of target cells, to isolate target cells and putative genetic modifiers.