A method of forming microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the concurrent polymerization of monomers, oligomer and/or prepolymers on the inside of the capsule wall and different monomers, oligomers and/or prepolymers on the exterior of the capsule wall as it forms.

The present invention relates to biomarkers associated with multiple sclerosis (MS), particular GLX molecules, and teven more particular GLX-related glycosaminoglycans (GAGs) and GLX-related proteoglycans (PGs).

A carbonation machine may include a carbonation head, a holder that is configured to hold a gas canister, the holder comprising a connector with a socket configured to enable linear insertion of a valve of the canister into the socket, the socket including a seal with at least one lateral opening to enable fluidic flow between one or more laterally oriented ports of the valve and a conduit of the holder while preventing leakage of gas from the fluidic flow, and a holding mechanism configured to hold a lateral projection from the canister after insertion of the valve into the socket such that the valve remains in the socket, and an activation mechanism configured to operate the valve to release the gas from the canister when inserted into the socket so as to enable the gas to flow via the conduit to the carbonation head.

The disclosed apparatus, systems and methods relate to devices, systems and methods for mixing particulate matter such as salt with moisture. In various implementations, the mixer is transportable. In various implementations the mixer comprises a hopper, at least one auger, and a mixing housing. Various implementations, additionally include at least one liquid tank.

A foam production method includes mixing liquid nitrogen with a foaming material to produce foam. A gas is produced in situ from liquid nitrogen. As the ratio of the volume of the gas produced by gasification of liquid nitrogen to the volume of the liquid nitrogen is relatively high, when a large gas supply flow is needed to generate a large foam flow, a liquid nitrogen storage device of a small volume can be used instead of bulky air supply devices such as high-pressure gas cylinders, air compressors, air compressor sets and the like, reducing the volume of the air supply device. In addition, the liquid nitrogen used in foaming will release nitrogen gas after the foam blast, such that the nitrogen is also able to inhibit combustion on the surface of burning materials, accelerating the extinguishing of the fire.

The present invention provides a humidifier capable of preventing water generated by dew condensation of vapor from being combined with air, so that an air humidity can be stably controlled. A humidifier 5 according to the present invention includes a storage tank 51 that stores water, the storage tank being opened upward; a heater 52 that heats the water in the storage tank 51; and a guide plate 53 that is disposed above the storage tank 51, on at least one of one side and the other side in a first direction D1 extending along a horizontal direction, with respect to a center of the storage tank 51. The guide plate 53 extends in an inclined manner such that an upper part thereof is positioned closer to the center of the storage tank 51 in the first direction D1, than a lower part thereof.

A reaction apparatus includes a hollow chamber with a stirring shaft. The chamber is maintained at a predetermined pressure and accepts at least two reactants from two storage tanks. The stirring shaft rotates around an axis and creates a reaction product. Taylor vortexes are created while the pressure minimizes the volume possession of the gas phase. The reaction product of micron and sub-micron particles is removed from the chamber and depressurized.

Settling unconverted pitch from a SHC reactor effluent before fractionation improves efficiency of fractionation of slurry hydrocracked products. The recycle of soft pitch to the SHC reactor results in improved reactor operation by avoiding the recycle of lighter products which vaporize in the reactor to occupy reactor space and the recycle of hard pitch which will not convert. The settling step facilitated by mixing with a solvent can achieve a separation between soft pitch and hard pitch not achievable in a fractionation column.

A method of forming microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the concurrent polymerization of monomers, oligomer and/or prepolymers on the inside of the capsule wall and different monomers, oligomers and/or prepolymers on the exterior of the capsule wall as it forms.

Disclosed herein are stable complexes with controlled particle size, increased apparent solubility and increased dissolution rate comprising as active compound Celecoxib, its salts, or derivatives thereof, which is useful in the treatment of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain especially in cancer related acute pain, primary dysmenorrhea. More specifically, the complexes possess instantaneous redispersibility, increased apparent solubility and permeability that provide faster onset of action for acute pain relief and lower GI related side effects. Further disclosed are methods of formulating and manufacturing the complexes described herein, pharmaceutical compositions, and uses and methods of treatment.