A process for the preparation of an erodible tamper-resistant dosage form that comprises a therapeutic agent-substrate complex embedded in a thermo-formable matrix, such that the complex includes at least one therapeutic agent bound to at least one substrate to form the therapeutic agent-substrate complex. The at least one substrate is being selected from a polyelectrolyte, an organic counter-ion, a pharmacologically inert organic component of a prodrug, an inclusion compound and an inorganic adsorbent; and the thermo-formable matrix includes one or more thermoplastic polymers and optionally at least one pharmaceutical additive. The dosage form provides resistance to intentional or unintentional tampering such as chewing, crushing and grinding, and volatilization.

There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.

Apparatus for injection of fluid into an extruder is provided, including a static mixer section with a pipe assembly coupled with the static mixer outlet and leading to the extruder barrel; the pipe assembly outlet and barrel injection opening have diameters less than the maximum internal diameter of the static mixer casing. The invention greatly simplifies the fluid injection apparatus used with extruders, while giving more efficient absorption of thermal energy with a minimum of environmental contamination, and the ability to inject multiple streams into the extruder.

Apparatus for injection of fluid into an extruder is provided, including a static mixer section with a pipe assembly coupled with the static mixer outlet and leading to the extruder barrel; the pipe assembly outlet and barrel injection opening have diameters less than the maximum internal diameter of the static mixer casing. The invention greatly simplifies the fluid injection apparatus used with extruders, while giving more efficient absorption of thermal energy with a minimum of environmental contamination, and the ability to inject multiple streams into the extruder.

A seal assembly includes a seal body having a space formed therein; a seal carrier held within the space, the seal carrier being selectively positionable between a sealing position and a rotation position by moving along a carrying path; at least one seal carried by the seal carrier; and a hermetic seal held within the space out of the carrying path of the seal carrier, the hermetic seal being configured to be abraded away by a rotating element that the hermetic seal is pressing against.

A mixer for ceramic feedstock pellets with a tank, a mixing shaft, and a heat exchanger including a cooler for the cooling of the content of this tank is provided. A controller controls the heat exchanger which includes a heater arranged to heat the content of this tank to a temperature comprised between a lower temperature (TINF) and a higher temperature (TSUP) stored in a memory for a specific mixture, and the heater exchanges energy with a heat exchange and mixing temperature maintenance circuit, external to this tank, and wherein the thermal inertia of this circuit is higher than that of this fully loaded tank. The invention also concerns a method for mixing raw material for powder metallurgy, implementing a specific injection molding composition and a specific binder.

Apparatus (20) for injection of fluid into extrusion system components such as a preconditioner (24) or extruder (100) is provided, preferably as a composite assembly including a fluid injection valve (52) and an interconnected static mixer section (54). Alternately, use may be made of the fluid injection valve (52) or static mixer section (54) alone. The invention greatly simplifies the fluid injection apparatus used in extrusion systems, while giving more efficient absorption of thermal energy with a minimum of environmental contamination, and the ability to inject multiple streams into the extrusion systems.

An extruder (100) for comestible material comprises a tubular barrel (104) and one or more elongated, axially rotatable, helically flighted screws (120, 122) within the barrel (104), where the barrel (104) has a delivery opening (114a). The extruder barrel (104) is equipped with an assembly (22) for delivery of fluid to the interior thereof, including a static mixing section (54) operable to blend the steam and water to create a blended mixture; the blended mixture is delivered to the barrel opening (114a) by means of a conveying assembly (84, 86) having a pipe assembly (86) with an outlet in communication with the barrel opening (114a); the pipe assembly (86) and opening (114a) have diameters less than maximum internal diameter of the static mixer casing (72).

A method for extruding a comestible material comprises the steps of passing comestible material into an extruder (100) with rotation of the extruder screw(s) (120, 122) and delivery of fluid comprising steam and water into an opening (114a) of the extruder barrel (104). The fluid delivery step comprises separately directing individual quantities of steam and water into the casing (72) of a static mixing section (54), and blending the steam and water to create a blended mixture, and then delivering the blended mixture into the barrel (114a). The blended mixture is delivered to the barrel opening (114a) by means of a conveying assembly (84, 86) having a pipe assembly (86) with an outlet in communication with the barrel opening (114a); the pipe assembly (86) and opening (114a) have diameters less than maximum internal diameter of the static mixer casing (72).

Apparatus (20) for injection of fluid into extrusion system components such as a preconditioner (24) or extruder (100) is provided, preferably as a composite assembly including a fluid injection valve (52) and an interconnected static mixer section (54). Alternately, use may be made of the fluid injection valve (52) or static mixer section (54) alone. The invention greatly simplifies the fluid injection apparatus used in extrusion systems, while giving more efficient absorption of thermal energy with a minimum of environmental contamination, and the ability to inject multiple streams into the extrusion systems.