Methods, systems and devices for PFAS destruction including adding a sulfite salt to an aqueous solution containing PFAS and then irradiating the aqueous solution with light at 222 nm. The method may include adding a base to the aqueous solution in an amount sufficient to raise a pH of the aqueous solution including PFAS to about 10 or more. It may also include adding a halide salt such as a bromide salt or an iodine salt, and further adding a carbonate. Greater than 90%, or greater than 99%, of the PFAS in the solution may be destroyed by irradiating the aqueous solution in this way.

An automated end-to-end continuous purification system for the manufacture of therapeutic proteins to reduce complexity of manual process operations and minimize physical space requirements, such system comprising a housing containing a control system, a tray and a collection vessel, wherein the system comprises a series of four purification stages, each such stage comprising a product pump and protein product line, a buffer pump and buffer line, a flow kit, two to four pinch valves and a waste line, and all such purification stages are connected by a single protein product line and are operated simultaneously.

An automated end-to-end continuous purification system for the manufacture of therapeutic proteins to reduce complexity of manual process operations and minimize physical space requirements, such system comprising a housing containing a control system, a tray and a collection vessel, wherein the system comprises a series of four purification stages, each such stage comprising a product pump and protein product line, a buffer pump and buffer line, a flow kit, two to four pinch valves and a waste line, and all such purification stages are connected by a single protein product line and are operated simultaneously.

Methods, systems, and devices for PFAS destruction including providing water containing PFAS to a reactor vessel, irradiating the water with UV light under conditions to destroy at least a portion of the PFAS, passing the treated water through a selective membrane to form permeate and membrane reject comprising PFAS, providing the membrane reject back to the reactor vessel, providing additional water containing PFAS to the reactor vessel within the reactor vessel or before being provided to the reactor vessel, and irradiating the membrane reject and the additional water containing PFAS within the reactor vessel with UV light. The steps may be repeated a plurality of times such that PFAS that is not destroyed is recycled through the reactor vessel. Sensitizers may be added and may also be recycled in the membrane reject with the PFAS.

Methods, systems, and devices for PFAS destruction including providing water containing PFAS to a reactor vessel, irradiating the water with UV light under conditions to destroy at least a portion of the PFAS, passing the treated water through a selective membrane to form permeate and membrane reject comprising PFAS, providing the membrane reject back to the reactor vessel, providing additional water containing PFAS to the reactor vessel within the reactor vessel or before being provided to the reactor vessel, and irradiating the membrane reject and the additional water containing PFAS within the reactor vessel with UV light. The steps may be repeated a plurality of times such that PFAS that is not destroyed is recycled through the reactor vessel. Sensitizers may be added and may also be recycled in the membrane reject with the PFAS.

Methods, systems and devices for removing iodide from an aqueous solution including submerging an iodophilic electrode in an aqueous solution containing iodide, applying a current to the electrode, and electrochemically oxidizing the iodide to iodine within the electrode. The electrode may include an iodophilic material and an electrically conductive material. It may also include a binder. The iodophilic material may be a starch, chitosan, carboxycellulose, cationic polymer, or an anion exchange membrane material, for example. After oxidizing the iodide to iodine within the electrode, the electrode may be submerged in a second solution and a current may be applied to reduce the iodine and release it from the electrode in the form of iodide into the second solution.

Methods, systems and devices for removing iodide from an aqueous solution including submerging an iodophilic electrode in an aqueous solution containing iodide, applying a current to the electrode, and electrochemically oxidizing the iodide to iodine within the electrode. The electrode may include an iodophilic material and an electrically conductive material. It may also include a binder. The iodophilic material may be a starch, chitosan, carboxycellulose, cationic polymer, or an anion exchange membrane material, for example. After oxidizing the iodide to iodine within the electrode, the electrode may be submerged in a second solution and a current may be applied to reduce the iodine and release it from the electrode in the form of iodide into the second solution.

An automated end-to-end continuous purification system for the manufacture of therapeutic proteins to reduce complexity of manual process operations and minimize physical space requirements.

A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method includes carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material; c) eluting the trapped 18F from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of treating the anion exchange material with water between two consecutive runs. Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.

A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method includes carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material; c) eluting the trapped 18F from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of treating the anion exchange material with water between two consecutive runs. Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.