Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

An apparatus and a method for removing salts from a liquid are described. A first liquid containing at least one salt is mixed with magnetic composite particles. A subsequent separation of the particles from the liquid is achieved using an electromagnetic source.

A method and apparatus for continuous magnetic filtration of ferrous mill scale from liquid solution employs a tank for receipt of fluids laden with mill scale. A curvate trough within the tank receives a rotatable magnetic drum and establishes a channel therebetween. An air compressor and associated manifold generate bubbles within the tank and adjacent the rotatable magnetic drum. The mill scale attaches to the bubbles, which are attracted to the surface of the drum where the mill scale accumulates. The accumulation of mill scale particles is moved about the surface of the rotating drum by a scraper proximate the surface thereof. By moving the accumulated mill scale particles to regions of the rotating drum that are of a magnetic force insufficient to retain them upon the surface of the drum, the mill scale particles are removed and passed to a conveyor system.

Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permit for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).

A nonaqueous electrolyte secondary battery separator film transfer device is provided which realizes a foreign object removing technique that is less likely to cause defects in a separator. The device includes a magnet bar which is arranged in a transfer path and generates a magnetic field for removing, from a separator film being transferred, a magnetic substance adhering to a first surface of the separator film; and an air cylinder which allows a distance to the magnet bar from the first surface of the separator film to be variable.

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

An apparatus and a method for removing salts from a liquid are described. A first liquid containing at least one salt is mixed with magnetic composite particles. A subsequent separation of the particles from the liquid is achieved using an electromagnetic source.