B04B5/00

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Rotary vessel for a filter assembly having a releasable locking device

A rotary vessel for a filter assembly is rotatably mountable in a housing of the filter assembly and has a body having an open end, a cover receivable on the body to close the open end, and a releasable locking device that is manually operable to selectively lock and unlock the cover relative to the body.

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Inside-out rotating coalescer with gas exit through hollow shaft

Various example embodiments relate to rotating coalescers. One embodiment includes a housing comprising a first housing section having a blowby gas inlet structured to receive crankcase blowby gases from a crankcase. The housing further comprises an oil outlet. The rotating coalescer includes an endcap and filter media. The filter media is arranged in a cylindrical shape and is coupled to and positioned between the first housing section and endcap. The filter media is structured to filter the crankcase blowby gases passing through the filter media by coalescing and separating oils and aerosols contained in the crankcase blowby gases. The rotating coalescer includes a hollow shaft extending through the housing and positioned radially inside of the filter media. The hollow shaft forms a blowby gas outlet structured to route filtered crankcase blowby gases out of the housing. The rotating coalescer further includes a drive mechanism operatively coupled to the hollow shaft.

Separation assembly with a single-piece impulse turbine

A separation assembly comprises a housing, a jet that expels a fluid within the housing, and a turbine positioned within the housing. The fluid causes the turbine to rotate about a center rotational axis within the housing. The turbine comprises a first axial end, a second axial end, and a plurality of vanes extending axially relative to the center rotational axis from the first axial end to the second axial end. The plurality of vanes defines axially-extending channels between each of the plurality of vanes. The first axial end comprises a radially-extending structure that axially blocks the flow of the fluid through the first axial end. The second axial end does not comprise any structure that axially blocks the flow of the fluid through the second axial end.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Rotary Vessel for a Filter Assembly

A rotary vessel for a filter assembly is rotatably mountable in a housing of the filter assembly and has a body having an open end, a cover receivable on the body to close the open end, and a releasable locking device that is manually operable to selectively lock and unlock the cover relative to the body.