The present invention provides a nanoparticle mass purification system capable of purifying nanoparticles at high yield and high purify from a nanoparticle synthesis stock solution synthesized in large quantities, and reusing the used solvent by recovery, and a nanoparticle mass purification method using same.

The present invention provides a nanoparticle mass purification system capable of purifying nanoparticles at high yield and high purify from a nanoparticle synthesis stock solution synthesized in large quantities, and reusing the used solvent by recovery, and a nanoparticle mass purification method using same.

The present invention relates to a method for separating lymphocytes and/or stem cells from whole blood in an automated blood separation system, wherein the quality of the collected lymphocytes and/or stem cells fractions is increased and the cell collection procedure is further automated by use of an optical sensor comprised in a detector device to measure turbidity and colour in the claimed method and in a cell separator, which can be used to perform the claimed method. The method of the invention is particularly useful to collect lymphocytes and/or stem cells fractions from whole blood, wherein the contamination of the collected cell fractions by platelets, red blood cells and granulocytes is reduced.

A method for monitoring, controlling, and/or regulating the operation of a centrifuge, in particular a separator, during the centrifugal processing of a product, in particular when clarifying a product and/or when separating a product into different liquid phases. The centrifuge has a drum which can be rotated by a drive spindle, a drum mounting, and a drive motor. Force measurements are performed using one or more force sensors and analyzed, and an output is provided in the event of a deviation from a specified behavior and/or the analyses are used for or during the control and/or regulation of the operation of the centrifuge.

A vertical cuttings dryer (“VCD”) can be used to separate solid particulate from entrained liquid. In some examples, the VCD includes a screen mounted coaxially with an internal wiper housing that carriers a wiper sweeping out an annular space between the screen and wiper housing. The VCD may have a first motor connected through drive shaft to the screen and a second motor connect through a separate drive shaft to the wiper housing. A controller can independently control the speed of the first motor and the second motor to independently a magnitude of centrifugal force applied to material being processed as well as a residence time of the material being processed in the annular space.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a centrifuge (10), comprising a rotor (12), a drive shaft (14), on which the rotor (12) is supported, a motor (18), which drives the rotor (12) by means of the drive shaft (14), a supporting unit (30) having damping elements (36), each of which comprises a spring axis (36a), which supporting unit supports a rotational unit (19), which comprises the motor (18) together with the drive shaft (14) and the rotor (12), a sensor unit (82, 84) for sensing the rotational speed, a distance sensor (80) for determining imbalances of the rotational unit (19), which rotational unit rotates about an axis of rotation (14a), an acceleration sensor (88) for determining imbalances of the rotational unit (19), and a control and evaluation unit (90), which evaluates the data of the sensors (80, 82, 88), wherein the distance sensor (80) senses distance changes in an operative axis (36b). The invention is characterized in that the operative axis (36b) is oriented in relation to the axis of rotation (14a) in such a way that an angle between the operative axis (36b) and the axis of rotation (14a) of less than 90° including 0° results, at least in a projection onto a plane parallel to the operative axis (36b) and through the axis of rotation (14a).

Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation.

A method and device for performing direct quantitative real time PCR in a crude sample, wherein said sample is subjected to a centrifugal force sufficient to separate components of the sample into a supernatant and a pellet, and wherein said at least one light source and said at least one detector are positioned so that the excitation light impinges on the sample in a position above said pellet, and said detector detects light emitted from a position above said pellet.