Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.

Biosafety units, methods of making and sealing the same are disclosed herein. The present invention includes a unitary structure able to be validated for pharmaceutical manufacturing comprising: at least one controlled air, sealable, sterilizable cleanroom; a mechanical system room adjacent to and separate from the cleanroom comprising: one or more air handling units that provide conditioned air to the cleanroom; and one or more power busses that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources; an integrated fire suppression system integral to the cleanroom; and one or more corridor connectors, wherein a corridor can be attached at the corridor connector.

A popcorn popping assembly includes a popcorn popping kettle having a side wall extending from a bottom wall. The assembly includes a plurality of retainers. Each of the retainers includes a bottom wall extending between a pair of side walls. The side walls and the bottom wall define a cavity, and an aperture is formed in the bottom wall and defines an essentially closed shaped periphery. The assembly includes a plurality of studs, each configured to be inserted through a respective aperture of a respective retainer. A plurality of fasteners are each configured to be received within the cavity of a retainer and couple with a stud to secure the stud to the retainer. A temperature sensor may extend through at least one of the apertures. A stud may be configured to cooperate with the temperature sensor and hold the temperature sensor in a predetermined location.

A popcorn popping assembly includes a popcorn popping kettle having a side wall extending from a bottom wall. The assembly includes a plurality of retainers. Each of the retainers includes a bottom wall extending between a pair of side walls. The side walls and the bottom wall define a cavity, and an aperture is formed in the bottom wall and defines an essentially closed shaped periphery. The assembly includes a plurality of studs, each configured to be inserted through a respective aperture of a respective retainer. A plurality of fasteners are each configured to be received within the cavity of a retainer and couple with a stud to secure the stud to the retainer. A temperature sensor may extend through at least one of the apertures. A stud may be configured to cooperate with the temperature sensor and hold the temperature sensor in a predetermined location.

A clip applying apparatus is provided for connecting plastic clips to reinforcing bars. The clip applying apparatus will generally include a barrel, a hammer received in the barrel, and a main drive configured to reciprocate the hammer within the barrel. Other features may include a safety shield as well as a lockout lever which prevents proximal movement of the safety shield if a clip is not fully received within the barrel. Another feature which may be included is a clip door operably connected to a sliding-pivot channel defined in one of the barrel and the clip door. Still other features may include at least one guide slot disposed within the barrel to direct hammer movement, and a hammer bushing coaxial with the barrel to support the hammer.

Portable, hand held, battery operated, dieless, hydraulic crimping tools are provided with a working head and a tool frame. The working head has a head frame with an open access to a working area of the working head. The open access may be in the form of a C-shape. The working head has a nest to receive a crimping member. An indentor is attached to a piston within the tool frame. The piston moves the indentor between a home position adjacent the tool frame and an indenting position where the indentor impacts the crimping member.

A swivel knuckle assembly for interconnecting a motor and a supply line. The knuckle assembly may include a bearing member to reduce a coefficient of friction. A locking mechanism is disclosed to connect members of the knuckle assembly.

A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.

A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.

The present invention relates to a valve device comprising an elastic valve insert and a reception means for the valve insert. It further relates to a valve insert, an external functional means and a treatment apparatus, as well as a manufacturing method and methods in which the valve device of the invention may be employed.