The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human FKBP51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome of the animal, comprising a nucleotide sequence encoding a tetracycline transactivator (tTA) operably linked to a promoter; wherein the tTA is expressed upon activation of the promoter and binds the tetracycline response element, thereby causing expression of FKBP51. The invention also pertains to methods for screening for agents for the prevention and/or treatment of psychiatric disorders, such as depression.

The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.

The present invention provides an all-female progeny of a decapod crustacean. The invention further provides the newly created: WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean. The crossing of WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean resulted in a 100% homogametic all-WW female progeny.

A method of growing shellfish is disclosed. The method comprises obtaining a support tray (I) with recesses (7) where at least some of the recesses (7) incorporate means adapted to create a deliberately formed alphanumeric, written or pictorial mark on the shellfish as it grows. Shellfish spat are attached to at least some of the recesses (7) and the tray (I) is placed in water so that the spat grow into substantially mature shellfish within the recesses (7). The spat each grow generally in the shape of their respective recess (7) so that the mark is created on the shellfish as it grows.

A method of growing shellfish is disclosed. The method comprises obtaining a support tray (I) with recesses (7) where at least some of the recesses (7) incorporate means adapted to create a deliberately formed alphanumeric, written or pictorial mark on the shellfish as it grows. Shellfish spat are attached to at least some of the recesses (7) and the tray (I) is placed in water so that the spat grow into substantially mature shellfish within the recesses (7). The spat each grow generally in the shape of their respective recess (7) so that the mark is created on the shellfish as it grows.

The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for -1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.

[Object] To provide a signal transmission device and management system which are capable of transmitting a signal including information of an attachment target or information of the surrounding of an attachment target. [Solution] A management system includes: a signal transmission device which includes a housing that is attached to an object to be managed in a predetermined direction, a first optical power generation unit and a second optical power generation unit that have light receiving units on a first surface and a second surface facing outwardly in a predetermined direction, respectively, a first temperature sensor and a second temperature sensor that have thermal contacts on the first surface and the second surface, respectively, a communication control unit for transmitting a signal including temperature information detected by the first temperature sensor and the second temperature sensor using power generated by at least one of the first optical power generation unit and the second optical power generation unit; and an information processing device which has a control unit for receiving a signal transmitted from the signal transmission device and outputting the state information of an object to be managed to which the signal transmission device is attached on the basis of the temperature information detected by at least the first temperature sensor and the second temperature sensor.