A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

An apparatus for accommodating a beverage includes an outer vessel defining a vessel cavity for receiving a cooling agent, a container having a lid and a beverage receptacle and a port. The lid is configured for engagement with the outer vessel to releasably mount the container to the outer vessel. The beverage receptacle defines a receptacle chamber for accommodating a liquid beverage for consumption by a user. The receptacle chamber is isolated from the vessel cavity. The beverage receptacle comprises a thermal conductive material and is at least partially disposed within the vessel cavity of the outer vessel when the container is mounted to the outer vessel whereby thermal energy is transferred from the cooling agent to the liquid beverage. The port defines a port opening in fluid communication with the receptacle chamber to permit distribution of the liquid beverage to the user. The outer vessel and mounted container may be positioned within a freezing apparatus to freeze the cooling agent, e.g., water about the beverage receptacle.

An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

An object of the present invention is to provide a flow channel device which hardly generates air bubbles within a flow channel and includes: a base material having a groove; and a coating material which is integrated with the base material so as to cover the groove, in which the difference (θ1−θ2) between a contact angle (θ1) of a portion facing the groove in the coating material with respect to pure water and a contact angle (θ2) of the groove portion of the base material with respect to the pure water is −30° to 30°.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

A device comprising, a substrate having a droplet thereover, and an electrical source coupleable to the substrate. The electrical source is configured to apply a voltage between the substrate and the droplet using an electrode. The electrode has a first portion and a second portion non-symmetric to the first portion, the first and second portions defined by a plane located normal to a longitudinal axis and through a midpoint of a length of the electrode.

A mixer gun system includes a holder cap configured to separately store components in separate chambers. The components are selectively releasable through channels fluidly communicating with the separate chambers. The components are constituent materials for a bone cement mixture. A body forms a mixing chamber and is configured to receive the holder cap. The mixing chamber includes an opening corresponding with the channels for the separate chambers. A piston is disposed within the mixing chamber. A plunger is coupled to the piston and is configured to be biased toward the mixing chamber such that when the components are released into the mixing chamber a pressure developed by a biased motion of the plunger and piston infuses the components to form bone cement. Upon resetting the plunger and the piston, the bone cement is dispensed from the mixing chamber by the same biased motion. Methods of use are disclosed.

A device stores, mixes, and applies polymethylmethacrylate bone cement. The device comprises a first container for a first pasty component of the bone cement, a dispensing plunger arranged in the first container such that it can be shifted and serves for pressing the content of the first container out of a dispensing opening, a mixing facility for mixing the content of the first container, whereby the mixing facility is arranged in the first container and the mixing facility can be moved in the first container from outside for mixing, and at least one second container for at least one second component of the bone cement is arranged in or on said first container. The second container can be opened, such that the contents of the first container and second container can be mixed with each other in the first container, whereby at least a boundary surface of the first container is formed by a mobile volume compensation element.

A mug including a stirring unit connected to the liquid space of the mug, for stirring a beverage contained in the liquid space of the mug simultaneously by the same hand in which the mug is held, and in which mug the stirring unit includes a pumping space separate from the liquid space, and a pumping device connected to the pumping space, configured to increase and to decrease the pressure of air inside the pumping space in an alternating manner. In the mug according to the invention, a flow channel extends from the pumping space to the liquid space, enabling the flow of the beverage contained in the liquid space from the liquid space to the pumping space and from the pumping space to the liquid space, whereby a liquid flow can be formed in the flow channel, for stirring the beverage in the liquid space by the pumping device.