The present invention relates to a bioreactor for RNA in vitro transcription, a method for RNA in vitro transcription, a module for transcribing DNA into RNA and an automated apparatus for RNA manufacturing. Further, the use of a bioreactor for RNA in vitro transcription as described herein is part of the present invention. The present invention relates to an RNA in vitro transcription reactor designed to be operable in an automated manner under GMP-compliant conditions. In particular, said RNA in vitro transcription reactor allows repetitive use of DNA template for various RNA in vitro transcription reactions. Further, the invention relates to an apparatus for RNA manufacturing comprising (a) a module for template DNA synthesis, (b) a module for transcribing DNA into RNA comprising said RNA in vitro transcription reactor, and, optionally, (c) a module for RNA formulation.

A mixing apparatus containing a drive unit having a drive and a shaft that is pivotable about a pivot axis and is operatively connected to the drive. A pivotable receptacle is arranged on the shaft, where the pivot axis is oriented essentially horizontally, and the pivotable receptacle has a base plate and at least one retainer spaced therefrom, and the pivotable receptacle is configured in such a way that holders for containers can be inserted between the base plate and the at least one retainer in the direction of the pivot axis.

A mixing device for preparing a ready-to-use compound comprising at least one component, which is to be mixed before use, in a cartridge with a tubular mixing rod and a working method with this mixing device and cartridge. The insertion of the cartridge in the mixing device is simplified so that the device can be operated completely automatically, and dispensing of a cartridge to be mixed or a ready-mixed cartridge is preferably be made possible with automated handling means (robots). Because the cartridge holder has a clamping means with which the cartridge can be clamped on the bottle neck-like section, the clamping of the cartridge in the mixer is simplified and can be triggered by force, for example pneumatically.

A device for the processing of liquids and/or solids includes a disposable layer adapted to shield a working surface from coming into contact with, and being fouled by, the processed liquids and/or solids, and apparatus suitable to apply a negative pressure in a gap between the disposable layer and the working surface, thereby causing the disposable layer to adhere to the working surface.

A foaming device comprising a fluid inlet, a fluid outlet spaced apart from said fluid inlet and a fluid conduit extending from said fluid inlet to said fluid outlet, the fluid conduit defining a cavity characterised in that said fluid conduit comprises first and second plates at least one of which comprises a plurality of baffles projecting into the cavity of the fluid conduit, and wherein at least one plate is movable with respect to the other to vary the distance between said plates.

A bubble generation device includes: a metallic narrow tube (10) through which water passes; and a pump that pressure-feeds the water containing a gas component into the metallic narrow tube (10). A drawer (11) in which a path through which the water passes is narrower than the front and the rear thereof in the flow direction of the water is disposed on the inside of the metallic narrow tube (10). The drawer (11) has the rectangular cross section orthogonal to the flow direction. The gas component contained in the water is dissolved in the water by pressure-feeding the water to the drawer (11), bubbles are evolved due to a decrease in pressure in the drawer (11), turbulent flow is generated in the water in the drawer (11) to crush bubbles in the water by the shearing force thereof, and bubbles are crushed by a shock wave caused by transonic flow occurring in the water that has exited from the drawer (11).

Systems and methods are described, which relate to the control of additive dispensers to provide defined amounts of one or more additive compounds to water to produce customized water. A given additive dispenser may include multiple inputs and/or outputs. Predefined water profiles may be stored in memory. A given water profile may define the amounts of additives to be delivered by the additive dispensers to achieve desired water characteristics. A controller may determine actual water characteristics of input water based on corresponding sensor data, and may compare the actual water characteristics to desired water characteristics in order to determine the amount of additive or additives that should be delivered to the input water to achieve the desired water characteristics. The additive dispensers may be network-enabled and may include transceivers configured to receive instructions related to production of customized water from a user device.

A method includes mixing a first deionized water (DI) water from a first pipe and a second DI water from a second pipe in a merging pipe that is in fluid communication with the first pipe and the second pipe. An electrical resistivity of the first DI water is different from an electrical resistivity of the second DI water. A mixture of the first DI water and the second DI water is applied from the merging pipe onto a wafer.

A linear actuator member applies a vertical force to a vessel or to a holding apparatus in which a vessel is contained. A linear to angular motion constraining member such as a cage structure having a helical track translates linearly directed force and motion applied by the linear actuator member into a combined linear and rotational motion of the vessel. The combined vertical and rotational motion of the vessel in response to the vertical force is repeatable according to a predefined agitation pattern for mixing components in the vessel.

A food preparation appliance includes a food preparation pot, a rotatable tool for chopping food in the food preparation pot and a sensor, in particular for weight determination of a food in the food preparation pot. A control unit is provided and configured such that, when a food is comminuted by the tool, the control unit is able to determine, based on a sensor signal from the sensor, whether a predetermined chopping state of the food has been reached.