A method for the preparation of pharmaceutical products is provided that utilizes a machine having a containing liner, a dosing chamber for preparing at least one pharmaceutical product accommodated within the containing liner, and a pneumatic ventilation device for feeding two air flows through the dosing chamber and through the containing liner, respectively. Operation of the pneumatic ventilation device is selectively controlled so that the containing liner has inside a pressure lower than a pressure existing within the dosing chamber and than a pressure existing in the environment outside the containing liner itself.

Apparatus and methods for a mixing device are presented. The mixing device comprises a shaft and a plurality of blades attached to the shaft. The blades include a variable pitch angle configured to create axial fluid flow and radial fluid flow within a container. The apparatus includes a hub and a cage located at ends of the apparatus. The cage includes an open end configured to mate with a structure attached to the container. In further examples of the apparatus, the upper blade is configured to create axial flow in a substantially downward direction. The lower blade is configured to create axial flow in a substantially upward direction. The lower blade can create an axial flow that encounters the upper blade. A method includes locating a mixing apparatus within the container, inserting fluid within the container, rotating the mixing apparatus, and mixing the fluid.

Herein disclosed is a method of producing value-added product from light gases, the method comprising: (a) providing light gases comprising at least one compound selected from the group consisting of C1-C6 compounds and combinations thereof; (b) intimately mixing the light gases with a liquid carrier in a high shear device to form a dispersion of gas in the liquid carrier, wherein the dispersion is supersaturated with the light gases and comprises gas bubbles at least some of which have a mean diameter of less than or equal to about 5 micron(s); (c) allowing the value-added product to form and utilizing vacuum to extract unreacted light gases from the liquid carrier; (d) extracting the value-added product; wherein the value-added product comprises at least one component selected from the group consisting of higher hydrocarbons, hydrogen, olefins, alcohols, aldehydes, and ketones. A system for producing value-added product from light gases is also disclosed.

A mixing arrangement, and pump for supplying small particles suspended in a liquid to form slurry for delivery includes a container, a mixing and delivery pump having a first shaft, a rotor connected to the first shaft and arranged at an inner bottom of an inner space of the container, a first power device connected to the first shaft, and a stator having stator blades. The stator surrounds the first shaft. The arrangement includes a pump having an inlet, which is located in a stator space between two stator blades, and an outlet, and an outlet pipe having a second inlet opening connected to the outlet and a second outlet opening located outside the inner space.

A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.

A method for crystallizing succinic acid includes agitating a succinic acid reaction solution with a jet-flow agitator that is rotated at low speed and has a low volume power density; compared with the conventional agitators, the jet-flow agitator helps increase the uniformity of succinic acid particles, shorten the time required for crystallizing succinic acid, and raise the yield of the crystallized succinic acid as well as purity of crystallized succinic acid having a purity of 99.8-99.9%.

An engine system includes an internal combustion engine having an exhaust system with an SCR aftertreatment mechanism and a urea injector upstream the aftertreatment mechanism. A mixing mechanism is positioned fluidly between the urea injector and the aftertreatment mechanism and includes a turbulator and a swirler structured to increase mixing of the urea and exhaust gases. Related methodology is also disclosed.

A fluidic dispensing device includes a housing having a chamber that defines an interior space, and has an inlet port and an outlet port. A flow control portion has a flow separator feature. The flow separator feature is positioned adjacent the inlet port. A stir bar is located in the chamber, has a rotational axis, and has a plurality of paddles, with each paddle having a free end tip. The stir bar has a stir bar radius from the rotational axis to the free end tip. A guide portion confines the stir bar in a predetermined portion of the interior space of the chamber. A ratio of the stir bar radius and a clearance distance between the free end tip and the flow control portion is 5:2 to 5:0.025.

A self-propelling container having: a top; a bottom; a plurality of vertical walls extending between the bottom and the top; an inner bag for holding contents to be dispensed; a female coupling configured to receive and establish a friction seal with a male coupling of an external device for inserting or extracting the contents to or from the container after the friction seal is established between the female and male couplings; and at least one independent panel positioned inside the container; a compressible element associated with the at least one independent panel wherein during filling of the inner bag the compressible element is compressed, thus causing the at least one independent panel to exercise pressure onto the inner bag, and thus, helping to empty the inner bag.

A filling apparatus comprises a filling material reservoir and a filling chamber that is connected to the filling material reservoir with a filling opening configured to dispense filling material into cavities in the rotary press. A first rotatably driven stirrer blade wheel with one or more stirrer blades and a second rotatably driven stirrer blade wheel with one or more stirrer blades are arranged in the filling chamber. The first rotatably driven stirrer blade wheel has at least one of a different geometry, a different direction of rotation, or a different rotary speed, than the second rotatably driven stirrer blade wheel.