Non-invasive Ocular Drug Delivery Insert Technology. The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a “Fickian” or a linear profile according to the intend purpose or pathology. The insert can be prepared with different shapes (spherical or spherical dome) and/or architectures (monolithic/layered either with or without a drug core) allowing the incorporation of at least one drug which can be released at different rates. The size, shape and design of the insert is adjusted in order to tune the drug(s) delivery profile(s) and to inhibit the risk of displacement or expulsion.

Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

A polyester-based film having excellent scratch resistance, durability, transparency, and visibility and a process for preparing the same. The polyester-based film comprises a base layer and a coating layer on at least one side of the base layer. The light passage according to Relationship 1 is 91% or more, or the total transmittance for light of 380 nm to 780 nm is 92% or more, it has excellent optical properties, durability, visibility, and reliability. Thus, it can be applied to display devices such as smartphones, tablet PCs, and laptops. In addition, in the polyester-based film according to an embodiment, the strain with respect to tensile load satisfies a specific range, whereby it is possible to achieve the flexibility that hardly causes deformation even when a certain load is maintained for a long period of time. Thus, it can be applied to flexible display devices, particularly, foldable display devices.

The invention relates to a process for preparing polymeric particles, based on the use of a polyester polymer (PE) comprising units from a dicarboxylic acid component and a diol component, wherein at least 2 mol. % of the diol component is a poly(alkylene glycol). The process comprises the melt-blending of the aromatic polymer (P) with the PE, the cooling the blend and the recovery of the particles by dissolution of the PE into water. The present invention relates to polymeric particles obtained therefrom and to the use of these particles in SLS 3D printing, coatings and toughening of thermoset resins.

An in-mold coating includes graphene and a base material including an unsaturated polyester and/or a vinyl ester monomer. A part includes a main body formed of a polymeric sheet molding compound and an in-mold coating disposed on the main body, where the in-mold coating includes graphene and a base material that comprises an unsaturated polyester and/or a vinyl ester monomer. A method of creating an in-mold coating includes providing a base material comprising at least one of an unsaturated polyester and a vinyl ester monomer, and the method further includes adding graphene to the base material.

This invention relates to a new polyester which is particularly suitable for use in the manufacture of mass-produced articles characterised by excellent mechanical properties, in particular high tensile strength and tensile modulus, associated with a high barrier property against oxygen and carbon dioxide.

The invention includes a device for supplying preforms having a collar. The device comprising a file-forming slide for the preforms, and the slide comprises a fixed frame and elements for guiding the preforms. The guiding elements are mounted so as to be adjustable in terms of position on the frame so as to be adapted to different formats of preform. The frame comprises support plates that are fixed in a reference position on the frame by removable fastening means, the guiding elements being mounted so as to be adjustable on the support plates.

A low shrinkage low oligomer polyester film and a method for manufacturing the same are provided. The method includes forming at least one polyester composition into an unstretched polyester thick film and stretching the unstretched polyester thick film in a machine direction (MD) and a transverse direction (TD) at a stretch ratio of two to six times. The polyester composition includes 94% to 99.974% by weight of a polyester resin, 0.01% to 1% by weight of a primary antioxidant, 0.01% to 1% by weight of a secondary antioxidant, 0.003% to 2% by weight of a nucleating agent, and 0.003% to 2% by weight of a flow aid. The polyester resin has an intrinsic viscosity between 0.60 dl/g and 0.80 dl/g.

A multilayer sheet comprising first and second layers is provided. The first layer consists of a co-polyester. The second layer consists of a thermoplastic polyurethane elastomer having an elongation at break of greater than 200%, a hardness of 60A to 85D, an ultimate tensile strength of greater than about 5000 psi, and a light transmission between 400 nm and 800 nm of greater than about 75%. A mold is provided and the multilayer sheet is thermoformed over the mold to form a plurality of tooth-receiving cavities configured to receive and reposition a patient's teeth from a first arrangement toward a second arrangement. Excess material is trimmed from the thermoformed multilayer sheet to form a multilayer dental aligner.

This invention relates to a polymer composition that is particularly suitable for use in the manufacture of thermoformed articles, which can be biodegraded in industrial composting. This invention also relates to a process for the production of the said composition and articles obtained thereby.