The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.

The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.

The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.

A method of producing an extruded, powdered/granulated composition comprising an active pharmaceutical ingredient (API), by the steps of providing an API and a porous inorganic excipient, and processing them by an extrusion process to directly produce an extruded, powdered/granulated composition wherein the API is at least partially absorbed within the pores of the inorganic excipient. In preferred embodiments, the API is melted, or solubilised in a solubilizer.

There is provided a polymeric material comprising: a co-continuous or highly-continuous blend of polyethylene and polypropylene, the blend comprising a polyethylene phase and a polypropylene phase separated by a polyethylene/polypropylene interface; and one or more thermoplastics other than polyethylene and polypropylene, the one or more thermoplastics each having an interfacial tension with polypropylene higher than the interfacial tension of the polyethylene/polypropylene interface, wherein the one or more thermoplastics form discrete phases that are encapsulating each other, and wherein said discrete phases are comprised within the polypropylene phase of the co-continuous or highly-continuous blend or are located at the polyethylene/polypropylene interface. There is also provided a process for recycling a blend of thermoplastics comprising polyethylene, polypropylene and one or more other thermoplastics, the process comprising the step of melting and mixing the polyethylene, the polypropylene and the one or more other thermoplastics, thereby producing a polymeric material.

There is provided a polymeric material comprising: a co-continuous or highly-continuous blend of polyethylene and polypropylene, the blend comprising a polyethylene phase and a polypropylene phase separated by a polyethylene/polypropylene interface; and one or more thermoplastics other than polyethylene and polypropylene, the one or more thermoplastics each having an interfacial tension with polypropylene higher than the interfacial tension of the polyethylene/polypropylene interface, wherein the one or more thermoplastics form discrete phases that are encapsulating each other, and wherein said discrete phases are comprised within the polypropylene phase of the co-continuous or highly-continuous blend or are located at the polyethylene/polypropylene interface. There is also provided a process for recycling a blend of thermoplastics comprising polyethylene, polypropylene and one or more other thermoplastics, the process comprising the step of melting and mixing the polyethylene, the polypropylene and the one or more other thermoplastics, thereby producing a polymeric material.

A process for producing a biopolymer nanoparticles product is disclosed. In this process, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder having a screw configuration in which the feedstock is process using shear forces in the extruder, and a crosslinking agent is added to the extruder downstream of the feed zone. The biopolymer feedstock and plasticizer are preferably added separately to the feed zone. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent second section of the extruder downstream of the first section. In a post reaction section located after a point in which the crosslinking reaction has been completed, water may be added to improve die performance.

A process for producing a biopolymer nanoparticles product is disclosed. In this process, biopolymer feedstock and a plasticizer are fed to a feed zone of an extruder having a screw configuration in which the feedstock is process using shear forces in the extruder, and a crosslinking agent is added to the extruder downstream of the feed zone. The biopolymer feedstock and plasticizer are preferably added separately to the feed zone. The screw configuration may include two or more steam seal sections. Shear forces in a first section of the extruder may be greater than shear forces in an adjacent second section of the extruder downstream of the first section. In a post reaction section located after a point in which the crosslinking reaction has been completed, water may be added to improve die performance.

The invention relates to a device for metering bulk material, in particular plastics granulate, for machines processing plastics granulate, in particular for injection molding machines, wherein at least one material funnel (2) into which bulk material can be filled and which has a material valve is provided. A weighing container (4) connected to weighing scales is optionally arranged below the material valve. A control unit is provided for the weighing scales and material valves. The material valve is designed as a metering valve (3), in particular as a flap-type metering valve. The metering valve (3) consists of a part, a closure (7), movable via a horizontal axis (6) and a fixed part, a scraper (8). The movable part has an operating arm (9) for an actuator (5) and at the end facing towards the fixed part has a closure plate (10) having a scraper projection (11). In the closed state of the metering valve (3) the scraper projection (11) touches the scraper (8).

The invention relates to a device for metering bulk material, in particular plastics granulate, for machines processing plastics granulate, in particular for injection molding machines, wherein at least one material funnel (2) into which bulk material can be filled and which has a material valve is provided. A weighing container (4) connected to weighing scales is optionally arranged below the material valve. A control unit is provided for the weighing scales and material valves. The material valve is designed as a metering valve (3), in particular as a flap-type metering valve. The metering valve (3) consists of a part, a closure (7), movable via a horizontal axis (6) and a fixed part, a scraper (8). The movable part has an operating arm (9) for an actuator (5) and at the end facing towards the fixed part has a closure plate (10) having a scraper projection (11). In the closed state of the metering valve (3) the scraper projection (11) touches the scraper (8).