A process for producing a biocompatible three-dimensional article, the process comprising the steps of providing in an elastin derivative provision step a water-soluble elastin derivative, producing in a hydrogel production step a hydrogel for 3D bioprinting comprising said water-soluble elastin derivative, and 3D bioprinting in a bioprinting step the biocompatible three-dimensional article by extrusion of said hydrogel.

A matrix for the cultivation of biological cells and differentiation into neuronal cells consists of a polymer base body having a structured surface with a microstructure and a nanostructure embedded therein.

The present invention relates to a method for molding a self-supporting silk fibroin catheter stent, which comprises preparing an excellent catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material. The raw material is silk fibroin extracted from natural mulberry silk; and the mold is a hollow tubular mold, having an outer shell that is a transparent polyethylene straw with a diameter of 6 mm and an inner core that is a fiber rod FRP with a diameter of 3 mm, with the two ends being closed. The mold casting and freeze-drying molding process comprises the steps of casting; pre-freezing; removing the mold and placing the mold onto a pre-frozen freeze-drying plate; and freeze-drying. The freeze-drying procedure comprises: (1) a pre-freezing stage; (2) a freezing-vacuum transition stage; (3) a gradient temperature-rising and freeze-drying stage; and (4) a secondary freeze-drying stage. The freeze-drying procedure is strictly regulated in accordance with the specifications of freeze-dried stents. The prepared stent has a good shape, and good tolerance without adding any additional components. The stent presents a three-dimensional porous space structure, the process is simple, and the stent meets the requirements for tissue-engineered vascular stent in clinic.

Implantable medical constructs formed by winding using winding support structures that can be flexible and can be integrated into the medical construct with biocompatible fiber(s) and/or yarn(s) and at least one continuous length collagen fiber. The implantable medical construct can include open suture anchor apertures formed using posts during a winding sequence.

In one aspect, a method includes providing support material within which the structure is fabricated, depositing, into the support material, structure material to form the fabricated structure, and removing the support material to release the fabricated structure from the support material. The provided support material is stationary at an applied stress level below a threshold stress level and flows at an applied stress level at or above the threshold stress level during fabrication of the structure. The provided support material is configured to mechanically support at least a portion of the structure and to prevent deformation of the structure during the fabrication of the structure. The deposited structure material is suspended in the support material at a location where the structure material is deposited. The structure material comprises a fluid that transitions to a solid or semi-solid state after deposition of the structure material.

Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The artificial ovaries have spatial arrangements and cellular compositions that allow them to mimic native ovarian tissue. As such, they can be cultured or transplanted to support female endocrine function and/or the development of oocytes and/or eggs.

A material fabrication method comprises (a) fabricating a structure from a programmable amyloid material (PAM) ink comprising an amyloid monomer stabilized in a liquid solvent; and (b) contacting the structure with an agent which triggers polymerization of the amyloid monomer and stabilization of the structure.

Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: XY-Z-YX, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.

The toughness of a laminate is improved. A fiber-reinforced resin material contains a fiber material in a resin; and the fiber material contains high-rigidity fibers and fibroin fibers. According to the present invention, a laminate is formed by laminating and bonding a plurality of fiber-reinforced resin layers. A fiber-reinforced resin layer contains the high-rigidity fibers in a resin. A fiber-reinforced resin layer contains the fibroin fibers in a resin.

The invention relates to a method for producing a fiber composite molded part. The method includes the steps of i) applying a gelatine-containing matrix material onto a fiber material, ii) deforming the fiber material provided with matrix material, and iii) curing the fiber material provided with matrix material.