The invention is directed to a thermoforming packaging machine (1) for producing sealed packages (2) having a planar surface (3) and a shaped recess (4) comprising a sealing station (6) with a lower sealing tool (7) comprising of a first part (8) provided with a first seal seam support (8a) for supporting a first sealed seam (9) at the outer perimeter (10) of the planar surface (3) of the moulded product (2a) and a second part (11) provided with a second support (11a) provided with a seal seam support opening (12). The second support (11a) supports a second sealed seam (12a) on the planar surface (3) of the moulded product (2a) following the perimeter (13) of the shaped recess (4). The first part (8) and the second part (11) are separate parts which are detachable connected.

Embodiments herein include a cardiac stent-valve for transcatheter delivery being compressible to a compressed state for delivery, and expandable to an expanded state for implantation. The stent-valve including a stent with an axial inflow end and an axial outflow end, a plurality of leaflets arranged within the stent, and a sealing skirt for reduction or prevention of paravalvular leakage. In the expanded state, the sealing skirt includes a tubular inner wall and at least one pocket which is positioned on the tubular inner wall and comprises an outer wall which extends radially outward from the tubular inner wall. The pocket is configured to be distended radially outward in response to inflow of blood in the expanded state. In the expanded state, the outer wall of the pocket includes one or more pre-shaped bulges which extend radially outward from the outer wall of the pocket. Other embodiments are also included herein.

A cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on a skin surface, in which the miniaturized needles penetrates into skin; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the skin to achieve a targeted therapeutic effect.

An impulse welding bar (10) for welding plastics films is provided with a detachable non-stick coating (20) which is held on lateral flanks (24) of the impulse welding bar (10). In order to facilitate the replacement of a worn non-stick coating (20), retaining elements (22) are provided which are made of two or more parts and which act in a form-fitting manner in order to detachably fasten the non-stick coating (20) to both flanks (24) of the impulse welding bar (10), wherein first parts (26) of the retaining elements (22) are arranged on the flanks (24) of the impulse welding bar (10) and second parts (36) of the retaining elements (22) are arranged on the non-stick coating (20).

An impulse welding bar (10) for welding plastics films is provided with a detachable non-stick coating (20) which is held on lateral flanks (24) of the impulse welding bar (10). In order to facilitate the replacement of a worn non-stick coating (20), retaining elements (22) are provided which are made of two or more parts and which act in a form-fitting manner in order to detachably fasten the non-stick coating (20) to both flanks (24) of the impulse welding bar (10), wherein first parts (26) of the retaining elements (22) are arranged on the flanks (24) of the impulse welding bar (10) and second parts (36) of the retaining elements (22) are arranged on the non-stick coating (20).

A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.

Mould for producing plastic items obtained by the injection of thermoplastic material of the “hot melt” or polyamide type, the mould being made of flexible vulcanised silicone, rubber or other elastomers, the mould being formed by two parts which, when facing each other and attached, generate a series of compartments and channels that allow for the introduction of the melted thermoplastic material and the filling of the cavities with the shape of the item desired, and, in turn, allow for a vacuum to be generated, also removing the inside air from the mould by means of a series of conduits and channels; and a method or methodology for producing said plastic items by means of said mould, allowing for the reproduction of short and medium series of items produced with plastic materials, and in which a control system and a mould incorporating a means to be identified can be added to the method.

The present disclosure is directed to a compression belt for inflation and sealing devices. The device may include an inflation assembly, a heating assembly, and a drive mechanism. The inflation assembly may direct fluid between first and second overlapping plies of a flexible web material to inflate chambers between the plies. The heating assembly may be operable to heat the first and second plies of the web material to create a longitudinal heat seal that seals the fluid in the inflated chambers. The drive mechanism may drive the web material in a downstream direction. The drive mechanism may tension the web material against the heating assembly. The drive mechanism may include a first belt including a high grip material on a surface that contacts the web material to grip the web material during heating by the heating assembly.

The present disclosure is directed to a compression belt for inflation and sealing devices. The device may include an inflation assembly, a heating assembly, and a drive mechanism. The inflation assembly may direct fluid between first and second overlapping plies of a flexible web material to inflate chambers between the plies. The heating assembly may be operable to heat the first and second plies of the web material to create a longitudinal heat seal that seals the fluid in the inflated chambers. The drive mechanism may drive the web material in a downstream direction. The drive mechanism may tension the web material against the heating assembly. The drive mechanism may include a first belt including a high grip material on a surface that contacts the web material to grip the web material during heating by the heating assembly.

An apparatus for making a three-dimensionally curved object, said apparatus comprising a membrane having a moulding surface, which is configurable into a predetermined shape by individually adjusting an array of actuators acting on the surface opposite the moulding surface of said membrane, wherein the membrane is a ferromagnetic membrane and the actuators are provided with magnetic joints at the distal ends of said actuators.