A separation welding device for the sectional joining and sectional separation of weldable film layers includes a temperature-controlled working surface that is designed to support joinable and separable film layers and further includes an electrical heating device as well as a counterholder for sectionally applying pressure to the joinable and separable film layers, which delimits a variably adjustable working gap with the working surface and that includes two mutually spaced joining stamps and one separating stamp arranged between the joining stamps wherein the separating stamp and/or at least one joining stamp is moveably attached to the counterholder wherein provision can be made for the separating stamp and/or the joining stamp to each be assigned a force sensor and/or a motion sensor to calculate a separation sequence determined by the separating stamp and/or a joining sequence determined by the joining stamp.

A separation welding device for the sectional joining and sectional separation of weldable film layers includes a temperature-controlled working surface that is designed to support joinable and separable film layers and further includes an electrical heating device as well as a counterholder for sectionally applying pressure to the joinable and separable film layers, which delimits a variably adjustable working gap with the working surface and that includes two mutually spaced joining stamps and one separating stamp arranged between the joining stamps wherein the separating stamp and/or at least one joining stamp is moveably attached to the counterholder wherein provision can be made for the separating stamp and/or the joining stamp to each be assigned a force sensor and/or a motion sensor to calculate a separation sequence determined by the separating stamp and/or a joining sequence determined by the joining stamp.

The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.

An apparatus for forming a flange has a laminate component and a drum supporting the laminate component. A forming tool selectively engages the laminate component. A diaphragm member extends between the drum and the laminate component and selectively engages the forming tool. Movement of the diaphragm member deforms the laminate component away from the drum about an edge of the forming tool, and the laminate component maintains a substantially uniform thickness.

A fill packaging machine includes a vertical sealing means for folding a packaging film at its central part and continuously forming a vertical sealed portion at its side edge part to shape into a cylinder, and a lateral sealing means for forming lateral sealed portions in a direction perpendicular to the longitudinal direction of the packaging film. An easy separable sealed portion is continuously formed in the side edge part of the packaging film by the first vertical sealed portion forming section, and a vertical sealed portion having a partial non-sealed portion of a bottle mouth type is formed on the easy separable sealed portion by the second vertical sealed portion forming section. The first vertical sealed portion forming section is a pair of heat sealing rolls or heat sealing plates, a surface of at least one of which is made from an elastic material softer than a metal.

A fill packaging machine includes a vertical sealing means for folding a packaging film at its central part and continuously forming a vertical sealed portion at its side edge part to shape into a cylinder, and a lateral sealing means for forming lateral sealed portions in a direction perpendicular to the longitudinal direction of the packaging film. An easy separable sealed portion is continuously formed in the side edge part of the packaging film by the first vertical sealed portion forming section, and a vertical sealed portion having a partial non-sealed portion of a bottle mouth type is formed on the easy separable sealed portion by the second vertical sealed portion forming section. The first vertical sealed portion forming section is a pair of heat sealing rolls or heat sealing plates, a surface of at least one of which is made from an elastic material softer than a metal.

To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy.

Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 μm≦L2≦L−L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is μm.

Thermal curing of a potting material within a hole in a surface of a composite material is described utilizing a flexible vacuum compression device that includes a chemical-based heating pack. The vacuum compression device includes an internal compartment within a cavity that retains the chemical-based heating pack, and a vacuum port having a passage into the cavity. An end of the vacuum compression device includes an interface that forms an air-tight seal between the cavity and the surface when applied to a surface of the composite material. Drawing a vacuum via the vacuum port collapses the vacuum compression device and positions the chemical-based heating pack proximate to the surface, enabling heat from the chemical-based heating pack to thermally cure the potting material.

A mold release processing method according to an embodiment of the present invention includes the steps of: (a) providing a mold releasing agent, including a fluorine-based silane coupling agent and a solvent, and a mold of which the surface has a porous alumina layer; (b) applying the mold releasing agent onto the surface; and (c) heating, either before or after the step (b), the surface to a temperature not less than 40° C. and less than 100° C. in an ambient with a relative humidity of 50% or more.

Methods and apparatus for positioning a structure on a polymer layer are described. A method may involve forming a first polymer layer. The method may further involve positioning, by an apparatus, a structure on the first polymer layer, where the apparatus comprises a rod having a first end that supports the structure as the structure is being positioned and a plunger located around the first end of the rod that presses the structure onto the first polymer layer as the structure is being positioned. And the method may involve forming a second polymer layer over the first polymer layer and the structure, where the first polymer layer defines a first side of a body-mountable device and the second polymer layer defines a second side of the body-mountable device opposite the first side.