This disclosure provides gene therapy vectors comprising a polynucleotide encoding one or more isoforms of lysosome-associated membrane protein 2 (LAMP-2), and methods of using such gene therapy vectors for the treatment of Danon disease and other autophagy disorders.

Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by Paenibacillus family members and methods of using the same are provided. The display of heterologous molecules, such as peptides, polypeptides and other recombinant constructs, on the spore surface of Paenibacillus family members, using particular N-terminal targeting sequences and derivatives of the same, are also provided.

Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by Paenibacillus family members and methods of using the same are provided. The display of heterologous molecules, such as peptides, polypeptides and other recombinant constructs, on the spore surface of Paenibacillus family members, using particular N-terminal targeting sequences and derivatives of the same, are also provided.

Embodiments of the present disclosure relate to a vaccine composition comprising a bacterial strain with a deleted or inactive ntrX gene.

A mobile, self-contained system for enhancing plant growth comprising: a mobile structure comprising a plurality of wheels so that the system can be moved; a vessel supported by the structure; a recirculating pump supported by the structure and exterior to the vessel, the pump having a first discharge line and a second discharge line; a generator supported by the structure; a vessel outlet from a bottom portion of the vessel to the pump; and an aerator for injecting air into the first discharge line; wherein the first discharge line extends from the pump directly into the bottom portion of the vessel, such that the contents of the vessel can be recirculated by the pump from the vessel outlet back into the vessel through the first discharge line and the second discharge line extends from the pump and is adapted for discharging contents of the vessel directly into an irrigation system.

A mobile, self-contained system for enhancing plant growth comprising: a mobile structure comprising a plurality of wheels so that the system can be moved; a vessel supported by the structure; a recirculating pump supported by the structure and exterior to the vessel, the pump having a first discharge line and a second discharge line; a generator supported by the structure; a vessel outlet from a bottom portion of the vessel to the pump; and an aerator for injecting air into the first discharge line; wherein the first discharge line extends from the pump directly into the bottom portion of the vessel, such that the contents of the vessel can be recirculated by the pump from the vessel outlet back into the vessel through the first discharge line and the second discharge line extends from the pump and is adapted for discharging contents of the vessel directly into an irrigation system.

The present invention provides both compositions comprising Methylobacterium and compositions comprising Methylobacterium that are depleted of substances that promote growth of resident microorganisms on a lettuce plant or seed. Also provided are methods for improving lettuce production, methods of making the compositions, and methods of treating a lettuce plant or seed with the compositions comprising Methylobacterium.

The present invention provides both compositions comprising Methylobacterium and compositions comprising Methylobacterium that are depleted of substances that promote growth of resident microorganisms on a lettuce plant or seed. Also provided are methods for improving lettuce production, methods of making the compositions, and methods of treating a lettuce plant or seed with the compositions comprising Methylobacterium.

Coating composition for applying to a plant structure of a monocotyledonous plant from which roots and shoots are capable of growing, wherein the said coating composition comprises an organic carrier material and one or more biological agents that possess an activity against at least one or more pathogens of the said monocotyledonous plant.

Coating composition for applying to a plant structure of a monocotyledonous plant from which roots and shoots are capable of growing, wherein the said coating composition comprises an organic carrier material and one or more biological agents that possess an activity against at least one or more pathogens of the said monocotyledonous plant.