An easy-to-hold off-axis pen has a pen head, a barrel, and at least one forefinger support. The pen head is irregularly shaped and hollow. The barrel is connected with the pen head and is hollow to accommodate a cartridge and to be held. A detachable clip fastener is strip-shaped whose two ends are respectively disposed on the pen head and an off-axis part of the barrel. One end of the detachable clip fastener can be pulled by fingers. The at least one forefinger support is disposed on a sidewall of the off-axis part to support and locate the forefinger during writing. The present invention can further include middle finger abutments disposed on the off-axis part and thumb anti-slip parts disposed on the barrel to make the easy-to-hold off-axis pen easy to grasp and anti-slip, and make users comfortable to grasp.