A method is provided for shunting route setting of a centralized traffic control system. The method includes S1, acquiring a shunting operation plan from an interface of a SMIS and generating a shunting route sequence, by a centralized traffic control system; S2, adding an operation direction, a location identifier of a shunter, a current control mode of the shunter and a description of a next route based on an original shunter number of the centralized traffic control system; S3, configuring a manual setting mode and an automatic triggering mode for shunting route setting; S4, adding identifiers of the manual setting mode and the automatic triggering mode to shunter number display; and S5, in the manual setting mode, adding a shunting plan constraint state and a free setting state to a shunting route setting logic of the centralized traffic control system.