A device for filling and priming syringes is provided and comprises a support base, an engagement seat defined on the support base to receive a rear end of a syringe barrel of a syringe provided with a sliding plunger, engaging means defined at the engagement seat to cooperate with the syringe barrel for firmly holding the syringe to the engagement seat, a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat to generate an under-pressure in the volume comprised between the plunger and the engagement seat when the syringe is firmly engaged in the engagement seat, and a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat to generate an over-pressure in the volume comprised between the plunger and the engagement seat when the syringe is thinly engaged in the engagement seat.

A medication dispenser system and use thereof for providing exact personal dosing for a patient are provided. In one aspect, a method for dispensing medications is provided. The method includes the steps of: obtaining patient information and a list of the medications for the patient; calculating a personal dose of each of the medications for the patient using the patient and cross-medication interaction information; and preparing treatments each containing the personal dose of each of the medications in a single treatment. In another aspect a system for dispensing medications includes: a patient information component for obtaining patient information and a list of the medications for the patient; a dosage calculator component for calculating a personal dose of each of the medications for the patient using the patient information; and a medication dispenser component for preparing treatments each containing the personal dose of each of the medications in a single treatment.

A liquid medication dispensing machine capable of stirring a liquid medication contained in a liquid medication bottle in the machine with a simple structure is provided. The liquid medication dispensing machine supplying a liquid medication from a liquid medication bottle (23) containing the liquid medication to a prescription bottle includes a holder (78) holding a bottom (23B) of the liquid medication bottle (23), and a rotationally driving unit (61) generating rotary force and rotating the holder (78) and the liquid medication bottle (23) held by the holder (78) around a rotation axis (L3) extending along a center line (L2) of the liquid medication bottle (23).

A system for carbonating a personalized beverage may comprise a base container including at least one sidewall defining a liquid storage area, and a carbon dioxide storage member configured to be sealingly coupled to said base container. The system may further comprise a carbon dioxide cartridge configured to selectively release carbon dioxide when engaged with said carbon dioxide storage member, and wherein said carbon dioxide storage member further comprises a pressure regulator configured to, when actuated, release the said carbon dioxide from said carbon dioxide cartridge at a rate configured to carbonate a beverage within said liquid storage over a period of time greater than 6 hours and less than 36 hours.

A system for carbonating a personalized beverage may comprise a base container including at least one sidewall defining a liquid storage area, and a carbon dioxide storage member configured to be sealingly coupled to said base container. The system may further comprise a carbon dioxide cartridge configured to selectively release carbon dioxide when engaged with said carbon dioxide storage member, and wherein said carbon dioxide storage member further comprises a pressure regulator configured to, when actuated, release the said carbon dioxide from said carbon dioxide cartridge at a rate configured to carbonate a beverage within said liquid storage over a period of time greater than 6 hours and less than 36 hours.

The device (1) has a housing (2), and a flexible bag arranged in the housing and intended to receive a liquid. A dispensing device, in particular an injection syringe (5), is also arranged in the housing, so that it is removable from the housing. A transfer channel (6) serves for direct or indirect transfer of the liquid from the bag into the dispensing device. At least one pressure plate (7) is also provided, which can be pressed against the bag in order to empty the bag. The pressure plate is preferably activated via a spring mechanism (16), which serves as energy accumulator. The device, according to the invention, makes it possible, with a few manoeuvres, to prepare an injection liquid and deliver it to the injection syringe, with the substances being brought together by a largely automated procedure.

A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23). The dissolving solution can be easily filled in a bubble-free state in the two-chamber type combined container-syringe.

Embodiments disclosed herein include needle-free syringe and cap assemblies and filling tub systems. One embodiment of filling tub system includes a filling tub having exterior walls and a floor. The floor is formed into a plurality of sockets configured to receive and support a plurality of cap and syringe body assemblies, with each cap and syringe assembly received in a separate socket. Furthermore, each socket is configured to receive and support a syringe and cap assembly with contact only between one or more surfaces of the socket and selected outer surfaces of the cap. Methods of pre-filling a quantity of needle-free syringes are also disclosed.

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

A method for filling and closing pharmaceutical objects disposed in parallel rows in nests includes removing the objects from the nests at an inlet of a conveying device in a removal station and placing the objects into the conveying device. In the conveying device, the objects are fed in succession to a first weighing station and weighed, to filling station and filled and to a second weighing station and again weighed and to a closing station and/or crimping station and closed. After closing, the objects are removed from the conveying section. In every case, pre-sterilized objects are processed in an aseptic manner.