Embodiments generally relate to vial preparation methods and to vials prepared by such methods. Some embodiments relate to use of an apparatus, such as a lyophilization apparatus, to perform the methods. An illustrative vial preparation method comprises: housing a plurality of vials in a temperature-controlled environment, wherein the plurality of vials each have a volume of a substance therein and each defines an unfilled volume therein, each vial having a stopper partially inserted into an opening of the vial so that gas can transfer between the unfilled volume and an external volume; applying a vacuum to the environment to reduce pressure in the environment and in the unfilled volume of each vial to a first pressure level; venting an inert gas into the environment to raise the pressure in the environment and in the unfilled volume of each vial to a second pressure level; allowing the vials to rest in the environment at the second pressure level for a predetermined period; repeating the applying, venting and allowing at least once; and fully inserting the stopper into each opening to seal each vial after the repeating.

Embodiments generally relate to vial preparation methods and to vials prepared by such methods. Some embodiments relate to use of an apparatus, such as a lyophilization apparatus, to perform the methods. An illustrative vial preparation method comprises: housing a plurality of vials in a temperature-controlled environment, wherein the plurality of vials each have a volume of a substance therein and each defines an unfilled volume therein, each vial having a stopper partially inserted into an opening of the vial so that gas can transfer between the unfilled volume and an external volume; applying a vacuum to the environment to reduce pressure in the environment and in the unfilled volume of each vial to a first pressure level; venting an inert gas into the environment to raise the pressure in the environment and in the unfilled volume of each vial to a second pressure level; allowing the vials to rest in the environment at the second pressure level for a predetermined period; repeating the applying, venting and allowing at least once; and fully inserting the stopper into each opening to seal each vial after the repeating.

A product includes a container, and a use indicator carried inside the container so that, upon removal of a closure from the container or upon removal of flowable product from within the container, a coloration of the product changes irreversibly to indicate to a user that the product has been used.

A product includes a container, and a use indicator carried inside the container so that, upon removal of a closure from the container or upon removal of flowable product from within the container, a coloration of the product changes irreversibly to indicate to a user that the product has been used.

A product includes a use indicator carried by a container so that, upon removal of a closure from the container or upon removal of flowable product from within the container, a coloration of the product changes irreversibly to indicate to a user that the package has been used, wherein the container includes a wall recess and the use indicator is carried in the wall recess.

A product includes a use indicator carried by a container so that, upon removal of a closure from the container or upon removal of flowable product from within the container, a coloration of the product changes irreversibly to indicate to a user that the package has been used, wherein the container includes a wall recess and the use indicator is carried in the wall recess.

A sealing bolt for sealing a container (e.g. for fissile materials), the sealing bolt adapted to cooperate, in use, with a locking device for locking a container lid to a container body of the container. The sealing bolt includes an upper part (i.e. adapted to be manipulated by an operator using a tool), a lower part (cooperating with the locking device 46) and an axial rod connecting the upper and lower parts, the upper part, lower part and axial rod being arranged coaxially about an axis. An integrity element is disposed in the upper part and a release arrangement (a detachable conical end-piece 24 retained by a ball 34 and recess 32 arrangement) is disposed so as to be releasably attached to the lower part. The sealing bolt is movable, through a first operator actuation of the upper part, from a first state, in which the integrity element is intact, to a second state, in which the integrity element of the sealing bolt is visibly broken. The sealing bolt is movable, through a second operator actuation of the upper part, from the second state to a third state, in which the release arrangement is released, thereby enabling disengagement of the locking device and removal of the lid from the container body. A locking system for a container, a method of releasably sealing a container, and a method of unsealing a container, are also disclosed.

Method for manufacturing a pressurising device for a beverage container, wherein a gas container is provided having a filling opening, into which gas container an amount of dry ice is inserted through the filling opening, where after the filling opening is closed and the dry ice is allowed to sublimate.

Method for manufacturing a pressurising device for a beverage container, wherein a gas container is provided having a filling opening, into which gas container an amount of dry ice is inserted through the filling opening, where after the filling opening is closed and the dry ice is allowed to sublimate.

A sealable module, cooled electronic system and method are described relating to cooling a heat generating electronic device. The sealable module is adapted to be filled with a first cooling liquid and a heat transfer device having a conduction surface defines a channel for receiving a second cooling liquid. In one embodiment, at least a portion of the conduction surface or housing is shaped in conformity with the shape of the electronic component. Control of the second cooling liquid is also described. Transferring heat between the second cooling liquid and a third cooling liquid features in embodiments. A method of filling a container with a cooling liquid is further detailed.