A user-replaceable e-liquid reservoir for dispensing e-liquid, the reservoir being inserted into, or otherwise attached to, a portable, personal e-cigarette device and engaging with an electrical or electronic pump fluid transfer system in the device, the device including: an electrical or electronic pump, being configured to transfer e-liquid from the e-liquid reservoir to an atomizing unit in the device, the pump delivering a pre-defined or variable quantity of e-liquid from the reservoir; and in which the reservoir is not user-refillable.

The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth.

The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth.

A crate includes a base and a plurality of walls including a front wall. The front wall is movable between a retracted, open position and a closed position. In some embodiments, the front wall includes a frame, a first portion and a second portion. The first portion is hingeably connected to the frame and the second portion is hingeably connected to the first portion.

A fungal infection treatment includes a container comprised of a thermally conductive material. In this way the container can be heated by the boiled water when the boiled water is poured from the cup into the container. A cover is positionable on the container to close the container to inhibit the boiled water from being spilled from the container. A drape is provided that has an opening extending therethrough. In this way the drape can be positioned on a respective one of the user's appendages having the opening exposing a nail on the respective appendage. The container is positionable in the opening when the drape is positioned on the appendage. In this way the container can transfer heat from the boiled water to the nail on the respective appendage for treating a fungal infection of the nail bed.

A fungal infection treatment includes a container comprised of a thermally conductive material. In this way the container can be heated by the boiled water when the boiled water is poured from the cup into the container. A cover is positionable on the container to close the container to inhibit the boiled water from being spilled from the container. A drape is provided that has an opening extending therethrough. In this way the drape can be positioned on a respective one of the user's appendages having the opening exposing a nail on the respective appendage. The container is positionable in the opening when the drape is positioned on the appendage. In this way the container can transfer heat from the boiled water to the nail on the respective appendage for treating a fungal infection of the nail bed.

An aspect of the present disclosure may provide a rotation type elevating container which includes a storage container capable of storing contents; a lower member accommodating a lower portion of the storage container; and an upper member accommodating an upper portion of the storage container and provided to be movable relative to the lower member, wherein the storage container has a first state in which the storage container is concealed from an outside by the upper member and the lower member, and a second state in which the upper member is spaced apart from the lower member so that a portion of the storage container is observable from the outside.

Contact lens dispensers are provided including a pens dispenser having an interior and a dispensing end. A delivery screw is provided in the interior of the tubular housing. The delivery screw has a thread pitch and a plurality of contact lenses, one contact lens per pitch. Upon actuation of an actuator, each contact lens moves along the thread by a distance of one pitch and a single contact lens is dispensed from the dispensing end of the tubular housing. A case and disposable foil contact lens cartridge are also provided as a re a case and disposable contact lens foil spool, wherein actuation of push-buttons dispense contact lenses ready for immediate application onto an eye.

A device for providing support for a workpiece on an embroidery machine. The device has a base that is configured to fit on a rod of the embroidery machine, wherein the rod of the embroidery machine is located beneath a bobbin arm. First and second sides extend upward from the base and form a channel therebetween, the channel being configured to receive the bobbin arm of the embroidery machine. The first and second sides have upper edges that are configured to provide a support structure for a workpiece placed thereon, and preferably extend to a height that is substantially the same height as a top of the bobbin arm.

The present invention relates to a container including a container body with a removable tray wherein the container can house at least two materials that must be kept separate until use. The container also may have upwardly extending fingers in the removable tray for securing a material.